Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.34 |
| ▸ | CDK4 | P11802 | 6/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 4/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.32 |
| ▸ | AURKA | O14965 | 3/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | CDK1 | P06493 | 2/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.32 |
| ▸ | CDK7 | P50613 | 2/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24761207 | 0.78 | CDK4 (0.37) | CDK2CDK4PLK1CCNE1DYRK1A | |
| SCHEMBL29796659 | 0.78 | CDK4 (0.42) | CDK2CDK4PLK1CCNE1DYRK1A | |
| SCHEMBL24760759 | 0.77 | CDK2 (0.44) | CDK2CDK4PLK1CCNE1DYRK1A | |
| SCHEMBL24760928 | 0.76 | LMNA (0.44) | CDK2CDK4PLK1CCNE1DYRK1A | |
| SCHEMBL6842494 | 0.74 | ALDH1A1 (0.52) | BRAFTGFBR1EGFRJAK3MAPK10 | |
| SCHEMBL6840084 | 0.72 | KDM4B (0.46) | MKNK2 | |
| SCHEMBL26097473 | 0.72 | TGFBR1 (0.48) | TGFBR1PIK3CDPI4KAPIK3CGPI4KB | |
| SCHEMBL3568782 | 0.71 | CDK2 (0.59) | CDK2CDK4PLK1CCNE1CDK9 | |
| SCHEMBL6835784 | 0.70 | KDM4E (0.32) | DYRK1ADYRK2DYRK1BBRAFPIK3CD | |
| SCHEMBL2460112 | 0.69 | DYRK1B (0.34) | CDK2CCNE1DYRK1ADYRK2DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022157166-A1 | THIAZOLOPYRIMIDONES AS INHIBITORS OF DDR1/2 AND THERAPEUTIC USES THEREOF | Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) (ES) | 2022-07-28 | — | — | WO | disclosed |
| EP-4032896-A1 | THIAZOLOPYRIMIDONES AS INHIBITORS OF DDR1/2 AND THERAPEUTIC USES THEREOF | Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) (ES) | 2022-07-27 | — | — | EP | disclosed |