Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MYC | P01106 | 2/20 | 0.31 |
| ▸ | WDR5 | P61964 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PI4KA | P42356 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6840019 | 0.79 | EGFR (0.33) | CYP3A4EGFRBRAFJAK3MAPK10 | |
| SCHEMBL6840024 | 0.76 | KDM4E (0.46) | KDM4EALDH1A1NPSR1GAAMYC | |
| SCHEMBL6842494 | 0.76 | ALDH1A1 (0.52) | KDM4EALDH1A1NPSR1GAACYP3A4 | |
| SCHEMBL6839964 | 0.74 | MYC (0.31) | KDM4EALDH1A1MYCWDR5SMN1; SMN2 | |
| SCHEMBL30309300 | 0.71 | TGFBR1 (0.51) | KDM4EALDH1A1GAAPIK3CDPI4KA | |
| SCHEMBL1850971 | 0.71 | TGFBR1 (0.51) | KDM4EALDH1A1GAAPIK3CDPI4KA | |
| SCHEMBL6840084 | 0.71 | KDM4B (0.46) | KDM4EALDH1A1CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL24760933 | 0.70 | CDK2 (0.34) | EGFRBRAFJAK3MAPK10PIK3CD | |
| SCHEMBL18230478 | 0.70 | CCR1 (0.49) | KDM4EALDH1A1MYCWDR5CYP3A4 | |
| SCHEMBL141036 | 0.70 | CDK2 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040181066-A1 | Tyrosine kinase inhibitors | FRALEY MARK E (US) | 2004-09-16 | — | — | US | disclosed |
| WO-2003011838-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040181066-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | KDM4E 2200/4885ALDH1A1 3104/4885NPSR1 4046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.