Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4B | O94953 | 3/20 | 0.46 |
| ▸ | KDM5C | P41229 | 3/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.46 |
| ▸ | KDM4A | O75164 | 2/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.46 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24774090 | 0.78 | DYRK1A (0.35) | ALDH1A1MAPTNPC1HSD17B10MEN1 | |
| SCHEMBL24774281 | 0.78 | PTGS2 (0.39) | ALDH1A1MAPTNPC1HSD17B10MEN1 | |
| SCHEMBL21067987 | 0.74 | HSP90AA1 (0.55) | KDM4BKDM5CKDM5BKDM4AKDM6B | |
| SCHEMBL24774282 | 0.74 | KDM4E (0.40) | ALDH1A1MAPTNPC1HSD17B10MEN1 | |
| SCHEMBL28146826 | 0.73 | NPC1 (0.45) | ALDH1A1NPC1HSD17B10MEN1KMT2A | |
| SCHEMBL24774092 | 0.73 | BPTF (0.37) | ALDH1A1MAPTNPC1HSD17B10MEN1 | |
| SCHEMBL26643840 | 0.73 | CYP19A1 (0.35) | ALDH1A1NPC1HSD17B10KMT2ARAB9A | |
| SCHEMBL28996166 | 0.73 | HSP90AA1 (0.47) | ALDH1A1CYP3A4KDM4ECYP2C9LMNA | |
| SCHEMBL30252976 | 0.73 | HSP90AA1 (0.47) | ALDH1A1CYP3A4KDM4ECYP2C9LMNA | |
| SCHEMBL5361055 | 0.72 | KDM4E (0.52) | KDM5CKDM4AKDM6BKDM2AKDM3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040181066-A1 | Tyrosine kinase inhibitors | FRALEY MARK E (US) | 2004-09-16 | — | — | US | disclosed |
| WO-2003011838-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040181066-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | KDM4B 3350/4885KDM5C 2852/4885KDM5B 2618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.