Guanine

Guanine

SCHEMBL4007020

Cc1c[nH]c(=O)[nH]c1=O.Nc1cc[nH]c(=O)n1.Nc1nc2[nH]cnc2c(=O)[nH]1

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ATAD2 Q6PL18 1/20 0.41
DYRK1A Q13627 1/20 0.39
KDM4E B2RXH2 2/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
GLA P06280 1/20 0.38
PMP22 Q01453 1/20 0.38
HSD17B10 Q99714 1/20 0.38
XDH P47989 2/20 0.34
PNP P00491 3/20 0.33
PARP1 P09874 1/20 0.30
DHFR P00374 1/20 0.30
MAPT P10636 2/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
QTRT1 Q9BXR0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanine SCHEMBL5097008 0.93 ATAD2 (0.36) ATAD2DYRK1AKDM4EALDH1A1LMNA
Guanine SCHEMBL9468293 0.92 ATAD2 (0.35) ATAD2DYRK1AKDM4EALDH1A1LMNA
Guanine SCHEMBL4460112 0.90 ATAD2 (0.51) ATAD2DYRK1AKDM4EALDH1A1LMNA
Guanine SCHEMBL15718980 0.89 KDM4E (0.33) ATAD2DYRK1AKDM4EALDH1A1LMNA
Guanine SCHEMBL9468221 0.88 KDM4E (0.32) ATAD2DYRK1AKDM4EALDH1A1LMNA
Guanine SCHEMBL78999 0.87 DYRK1A (0.49) DYRK1AKDM4EALDH1A1LMNAGLA
Guanine SCHEMBL8470122 0.87 DYRK1A (0.49) DYRK1AKDM4EALDH1A1LMNAGLA
Adenine SCHEMBL4579096 0.85 ATAD2 (0.41) ATAD2PNPPARP1
Thymine SCHEMBL2476233 0.85 ATAD2 (0.58) ATAD2DYRK1AKDM4EALDH1A1LMNA
Thymine SCHEMBL536790 0.85 ATAD2 (0.58) ATAD2DYRK1AKDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3211086-B1 METHODS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, LABELING OF DNA PROBES AND THE USE OF THESE PROBES MENARINI SILICON BIOSYSTEMS SPA (IT) 2021-06-09 EP disclosed
US-11015227-B2 Methods and compositions to generate unique sequence DNA probes, labeling of DNA probes and the use of these probes MENARINI SILICON BIOSYSTEMS S.P.A. (IT) 2021-05-25 US disclosed
US-20180208998-A1 METHODS AND COMPOSITIONS TO GENERATE UNIQUE SEQUENCE DNA PROBES, LABELING OF DNA PROBES AND THE USE OF THESE PROBES MENARINI SILICON BIOSYSTEMS, INC. (US) 2018-07-26 US disclosed
US-9957571-B2 Methods and composition to generate unique sequence DNA probes, labeling of DNA probes and the use of these probes MENARINI SILICON BIOSYSTEMS, INC. (US) 2018-05-01 US disclosed
EP-3211086-A2 METHODS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, LABELING OF DNA PROBES AND THE USE OF THESE PROBES Janssen Diagnostics, LLC (US) 2017-08-30 EP disclosed
EP-1941050-B1 METHODS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, IABELING OF DNA PROBES AND THE USE OF THESE PROBES JANSSEN DIAGNOSTICS LLC (US) 2017-04-26 EP disclosed
US-20160046998-A1 METHDS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, LABELING OF DNA PROBES AND THE USE OF THESE PROBES MENARINI SILICON BIOSYSTEMS S.P.A. (IT) 2016-02-18 US disclosed
US-9127302-B2 System for the detection and enumeration of suspect target cells in a mixed cell population JANSSEN DIAGNOSTICS, LLC (US) 2015-09-08 US disclosed
US-20090220955-A1 METHODS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES LABELING OF DNA PROBES AND THE USE OF THESE PROBES VERIDEX LLC 2009-09-03 US disclosed
EP-1941050-A4 METHODS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, IABELING OF DNA PROBES AND THE USE OF THESE PROBES IMMUNIVEST CORP (US) 2009-06-24 EP disclosed
EP-1941050-A2 METHODS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, IABELING OF DNA PROBES AND THE USE OF THESE PROBES IMMUNIVEST CORPORATION (US) 2008-07-09 EP disclosed
WO-2007053245-A2 METHODS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, IABELING OF DNA PROBES AND THE USE OF THESE PROBES IMMUNIVEST CORPORATION (US) 2007-05-10 WO disclosed
EP-1481075-A2 AMINO ACID-PRODUCING BACTERIA AND A PROCESS FOR PREPARING L-AMINO ACIDS Degussa AG (DE) 2004-12-01 EP disclosed
WO-2003074719-A2 AMINO ACID-PRODUCING BACTERIA AND A PROCESS FOR PREPARING L-AMINO ACIDS DEGUSSA AG (DE) 2003-09-12 WO disclosed