Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 7/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2476183 | 0.83 | ALOX5 (0.42) | PDCD1LG2CD274CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL23456217 | 0.75 | ALDH1A1 (0.46) | PDCD1LG2CD274CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL10094337 | 0.73 | PRKCZ (0.47) | PRKCZKCNA5KCNH2CYP11B2CYP17A1 | |
| SCHEMBL2473298 | 0.72 | PDCD1LG2 (0.44) | PDCD1LG2CD274CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL2477497 | 0.72 | PDCD1LG2 (0.39) | PDCD1LG2CD274CYP2C19 | |
| SCHEMBL20873066 | 0.72 | PRKCZ (0.64) | PRKCZKCNA5KCNH2CYP11B2CYP17A1 | |
| SCHEMBL2474097 | 0.71 | MAPT (0.40) | PDCD1LG2CD274ERN1 | |
| SCHEMBL2478734 | 0.71 | PDGFRB (0.41) | PDCD1LG2CD274CYP1A2EGFR | |
| SCHEMBL2480866 | 0.70 | HDAC4 (0.42) | PDCD1LG2CD274CYP1A2 | |
| SCHEMBL1588343 | 0.70 | ESR1 (0.41) | PDCD1LG2CD274CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2159216-B1 | 3-BUTENYL-1-AMINE DERIVATIVES AND THEIR USE AS Ih MODULORS FOR THE TREATMENT OF PSYCHIATIRC DISORDERS | ORGANON NV (NL) | 2011-10-12 | — | — | EP | disclosed |
| EP-2159216-A1 | Ih - Modulators | N.V. Organon (NL) | 2010-03-03 | — | — | EP | disclosed |
| US-20020037885-A1 | Therapeutic compounds | DIJCKS FREDERICUS ANTONIUS (NL) | 2002-03-28 | — | — | US | disclosed |
| US-6313139-B1 | ADMINISTERING BENZYLAMINE DERIVATIVE FOR THERAPY OF PSYCHIATRIC DISORDER IN MAMMALS | AKZO NOBEL N. V. (NL) | 2001-11-06 | — | — | US | disclosed |
| US-6080773-A | USEFUL FOR TREATMENT OF DEPRESSION, ANXIETY OR PSYCHOSIS | AKZO NOBEL, N.V. (NL) | 2000-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037885-A1 | Therapeutic compounds | BDNF, PNMT, SLC18A2 | PRKCZ 3155/4885KCNA5 890/4885KCNH2 1706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.