Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 3/20 | 0.38 |
| ▸ | CCND1 | P24385 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 5/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | GRK6 | P43250 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27827799 | 0.78 | P2RX7 (0.53) | CDK4CCND1CNR2P2RX7KMT2A | |
| SCHEMBL27844923 | 0.76 | MAPT (0.44) | CNR2MEN1LMNAHTTKMT2A | |
| SCHEMBL17069069 | 0.75 | XDH (0.39) | MEN1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL28990233 | 0.75 | OXER1 (0.46) | CDK4CCND1CNR2P2RX7 | |
| SCHEMBL15112345 | 0.74 | CNR2 (0.56) | CDK4CCND1CNR2DRD2DRD3 | |
| SCHEMBL17023237 | 0.73 | LMNA (0.45) | GRM2MEN1LMNAHTTKMT2A | |
| SCHEMBL2872955 | 0.73 | KMT2A (0.51) | MEN1LMNAHTTKMT2ATSHR | |
| SCHEMBL3821765 | 0.72 | GRM2 (0.44) | GRM2CNR2MEN1LMNAHTT | |
| SCHEMBL9684661 | 0.71 | GRK6 (0.39) | GRM2DRD2DRD3MEN1LMNA | |
| SCHEMBL22871225 | 0.70 | HTR2A (0.42) | DRD2DRD3MEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362874-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2011-09-07 | — | — | EP | disclosed |