Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 2/20 | 0.51 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306418 | 0.81 | ADRA1D (0.49) | ADRA1DLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6645686 | 0.79 | CYP17A1 (0.56) | ADRA1DTAAR1TSHRLMNAADRA2A | |
| SCHEMBL25185325 | 0.77 | ADRA1D (0.45) | ADRA1DTAAR1TSHRLMNACYP1A2 | |
| SCHEMBL559559 | 0.75 | TAAR1 (0.56) | ADRA1DTAAR1TSHRLMNAADRA2A | |
| SCHEMBL28301068 | 0.74 | EGFR (0.44) | ADRA1DTSHRLMNACYP1A2CYP3A4 | |
| SCHEMBL45228 | 0.74 | LMNA (0.50) | ADRA1DTAAR1TSHRLMNAALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL27757668 | 0.72 | LMNA (0.49) | ADRA1DTAAR1TSHRLMNAALDH1A1 | |
| Methane SCHEMBL11161392 | 0.72 | LMNA (0.49) | ADRA1DTAAR1TSHRLMNAALDH1A1 | |
| SCHEMBL9825918 | 0.72 | LMNA (0.49) | ADRA1DTAAR1TSHRLMNAALDH1A1 | |
| SCHEMBL28205872 | 0.72 | ADRA1D (0.47) | ADRA1DTAAR1TSHRLMNAADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022263800-A1 | PROCESS | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2022-12-22 | — | — | WO | disclosed |
| CN-101918358-B | Novel vitamin D receptor activators and methods of manufacture | ABBVIE (US) | 2015-10-14 | — | — | CN | disclosed |
| CN-104211626-A | NEW VITAMIN D RECEPTOR ACTIVATORS AND METHODS OF MAKING | ABBVIE INC | 2014-12-17 | — | — | CN | disclosed |
| CN-102816165-A | Amino-aza-adamantane derivatives and methods of use | ABBOTT LAB | 2012-12-12 | — | — | CN | disclosed |
| CN-101925599-A | Azabicyclic alkane derivatives as the biaryl substituted of nicotinic acetylcholine receptor activity modulators | ABBOTT LAB | 2010-12-22 | — | — | CN | disclosed |
| CN-101918409-A | The diazabicycloalkane derivatives of biaryl substituted | ABBOTT LAB | 2010-12-15 | — | — | CN | disclosed |
| CN-101918358-A | Novel vitamin D receptor activators and methods of manufacture | ABBOTT LAB | 2010-12-15 | — | — | CN | disclosed |
| CN-101309922-A | Amino-aza-adamantane derivatives and methods of use | ABBOTT LAB (US) | 2008-11-19 | — | — | CN | disclosed |