SCHEMBL8306418

SCHEMBL8306418

c1cncc(Cc2cccs2)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1D P25100 2/20 0.49
CYP3A4 P08684 3/20 0.47
CYP2C9 P11712 2/20 0.47
CYP2E1 P05181 1/20 0.47
CYP2A6 P11509 1/20 0.47
CYP2B6 P20813 1/20 0.47
HRH4 Q9H3N8 1/20 0.46
HRH3 Q9Y5N1 1/20 0.46
CYP1A2 P05177 3/20 0.46
CYP2D6 P10635 3/20 0.46
TBXAS1 P24557 3/20 0.44
CHRNA7 P36544 1/20 0.44
MMP2 P08253 1/20 0.44
NPC1 O15118 1/20 0.43
LMNA P02545 1/20 0.43
RAB9A P51151 1/20 0.43
CHRNB2 P17787 2/20 0.43
CHRNA4 P43681 2/20 0.43
ADAM17 P78536 1/20 0.43
ALDH1A1 P00352 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2884688 0.84 CHRNA7 (0.52) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
SCHEMBL24769737 0.81 ADRA1D (0.51) ADRA1DCYP3A4CYP2C9CYP1A2CYP2D6
SCHEMBL2886214 0.81 CYP2A6 (0.54) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
SCHEMBL2886638 0.81 TDP1 (0.57) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
SCHEMBL6645686 0.80 CYP17A1 (0.56) ADRA1DCYP3A4CYP2C9CYP1A2CYP2D6
Hydrochloric Acid SCHEMBL6122783 0.78 CYP1A2 (0.66) CYP3A4CYP2C9CYP1A2CYP2D6LMNA
SCHEMBL727185 0.77 CYP1A2 (0.62) CYP2A6HRH4HRH3CYP1A2CYP2D6
SCHEMBL45228 0.76 LMNA (0.50) ADRA1DCYP2C9NPC1LMNARAB9A
SCHEMBL9825918 0.74 LMNA (0.49) ADRA1DCYP2C9NPC1LMNARAB9A
SCHEMBL16996646 0.74 MMP2 (0.65) CYP2A6HRH4HRH3CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-57085335-A None JP disclosed
WO-2022263800-A1 PROCESS JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2022-12-22 WO disclosed
CN-103709096-B Urea type derivative used as nicotinamide ribose phosphate transferase inhibitor, as well as preparation method and application thereof 中国人民解放军第二军医大学 2017-01-18 CN disclosed
CN-103709096-A Urea type derivative used as nicotinamide ribose phosphate transferase inhibitor, as well as preparation method and application thereof UNIV PLA 2ND MILITARY MEDICAL 2014-04-09 CN disclosed
EP-0667855-B1 SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS ABBOTT LAB (US) 1999-03-24 EP disclosed
US-5616596-A Substituted arylalkynyl-and heteroarylalkynl-N-hydroxyurea inhibitors of leukotriene biosynthesis ABBOTT LABORATORIES (US) 1997-04-01 US disclosed
US-5506261-A Substituted aryl- and heteroarylalkenyl-N-hydroxyurea inhibitors of leukotriene biosynthesis ABBOTT LABORATORIES (US) 1996-04-09 US disclosed
EP-0667855-A4 SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS. ABBOTT LAB (US) 1996-02-21 EP disclosed
WO-1995030671-A1 SUBSTITUTED ARYL- AND HETEROARYLALKENYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS ABBOTT LABORATORIES (US) 1995-11-16 WO disclosed
EP-0667855-A1 SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS ABBOTT LABORATORIES (US) 1995-08-23 EP disclosed
WO-1994011342-A1 SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS ABBOTT LABORATORIES (US) 1994-05-26 WO disclosed
US-4415566-A ANTIBIOTICS; BACTERIOSTATS; BACTERICIDES BOEHRINGER INGELHEIM GMBH (DE) 1983-11-15 US disclosed
JP-S5785335-A PRODUCTION OF BISPHENOL MITSUBISHI CHEM IND LTD 1982-05-28 JP disclosed