Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PTPRC | P08575 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20218196 | 0.85 | CES1 (0.41) | CASP3CES1TTRMEN1KMT2A | |
| SCHEMBL19308154 | 0.78 | TTR (0.36) | CES1TTRMEN1KMT2ATDP2 | |
| SCHEMBL21998582 | 0.78 | TTR (0.36) | CES1TTRMEN1KMT2ATDP2 | |
| SCHEMBL13824480 | 0.78 | NR1H3 (0.49) | CASP3MEN1KMT2AALDH1A1BRD4 | |
| SCHEMBL8790761 | 0.77 | TTR (0.50) | CASP3CES1TTRALDH1A1BRD4 | |
| SCHEMBL3332344 | 0.77 | PTPRC (0.42) | CASP3CES1TTRMEN1KMT2A | |
| SCHEMBL21931643 | 0.77 | BLM (0.41) | CASP3CES1TTRMEN1KMT2A | |
| SCHEMBL19297675 | 0.77 | BRD4 (0.43) | CES1MEN1KMT2AALDH1A1TDP2 | |
| SCHEMBL562473 | 0.74 | ALDH1A1 (0.60) | CES1ALDH1A1 | |
| SCHEMBL22300876 | 0.73 | CYP1A2 (0.38) | CASP3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116098898-B | Application of oxindole compound of targeting MAGI2 GK domain in medicine for treating ischemic cerebral apoplexy | 中国人民解放军陆军军医大学 | 2025-05-16 | — | — | CN | disclosed |
| CN-116098898-A | Application of oxindole compound of targeting MAGI2GK domain in medicine for treating ischemic cerebral apoplexy | 中国人民解放军陆军军医大学 | 2023-05-12 | — | — | CN | disclosed |
| CN-109575050-B | Gossypol-7-N heteroisatin Schiff base compounds with anti-tumor activity and synthesis method thereof | 陕西盘龙药业集团股份有限公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-109438323-B | Gossypol-7-N heteroisatin Schiff base compounds with anti-tumor activity and synthesis method thereof | 陕西盘龙药业集团股份有限公司 | 2022-03-11 | — | — | CN | disclosed |
| US-10722500-B2 | Gossypol 7-N-isatin Schiff base compounds with antitumor activities and a method of preparing the same | SHAANXI PANLONG PHARMACEUTICAL GROUP LIMITED BY SHARE LTD. (CN) | 2020-07-28 | — | — | US | disclosed |
| US-20200147057-A1 | GOSSYPOL 7-N-ISATIN SCHIFF BASE COMPOUNDS WITH ANTITUMOR ACTIVITIES AND A METHOD OF PREPARING THE SAME | SHAANXI PANLONG PHARMACEUTICAL GROUP LIMITED BY SHARE LTD. (CN) | 2020-05-14 | — | — | US | disclosed |
| US-9868734-B2 | Conjugate of benzofuranone and indole or azaindole, and preparation and uses thereof | LUODA BIOSCIENCES, INC. (CN) | 2018-01-16 | — | — | US | disclosed |
| US-9751896-B1 | Asymmetric 7-N isatin dimer Schiff base compounds with antitumor activities and a method of preparing the same | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2017-09-05 | — | — | US | disclosed |
| US-9751896-B1 | Asymmetric 7-N isatin dimer Schiff base compounds with antitumor activities and a method of preparing the same | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2017-09-05 | — | — | US | disclosed |
| US-9751896-B1 | Asymmetric 7-N isatin dimer Schiff base compounds with antitumor activities and a method of preparing the same | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2017-09-05 | — | — | US | disclosed |
| US-20160185771-A1 | Conjugate of Benzofuranone and Indole or Azaindole, and Preparation and Uses Thereof | LUODA BIOSCIENCES, INC. (CN) | 2016-06-30 | — | — | US | disclosed |
| EP-3006442-A1 | CONJUGATE OF BENZOFURANONE AND INDOLE OR AZAINDOLE, AND PREPARATION AND USES THEREOF | Luoda Biosciences, Inc. (CN) | 2016-04-13 | — | — | EP | disclosed |
| US-8642765-B2 | Azaindole-indole coupled derivatives, preparation methods and uses thereof | Cheng, Jingcai (CN) | 2014-02-04 | — | — | US | disclosed |
| EP-2168964-B1 | AZAINDOLE-INDOLE COUPLED DERIVATIVES, PREPARATION METHODS AND USES THEREOF | CHENG JINGCAI (CN) | 2011-10-12 | — | — | EP | disclosed |
| US-20100137356-A1 | AZAINDOLE-INDOLE COUPLED DERIVATIVES, PREPARATION METHODS AND USES THEREOF | Cheng, Jingcai (CN) | 2010-06-03 | — | — | US | disclosed |
| EP-2168964-A1 | AZAINDOLE-INDOLE COUPLED DERIVATIVES, PREPARATION METHODS AND USES THEREOF | Cheng, Jingcai (CN) | 2010-03-31 | — | — | EP | disclosed |
| CN-101492465-A | 7,7'-diaza indirubin compounds for antineoplastic medicament | UNIV SHANGHAI JIAOTONG (CN) | 2009-07-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10722500-B2 | Gossypol 7-N-isatin Schiff base compounds with antitumor activities and a method of preparing the same | HASPIN, GGPS1, GNA15 | CASP3 1317/4885CES1 773/4885TTR 4315/4885 |
| US-20100137356-A1 | AZAINDOLE-INDOLE COUPLED DERIVATIVES, PREPARATION METHODS AND USES THEREOF | IDO1, IDO2, INMT | CASP3 445/4885CES1 2072/4885TTR 4334/4885 |
| US-20200147057-A1 | GOSSYPOL 7-N-ISATIN SCHIFF BASE COMPOUNDS WITH ANTITUMOR ACTIVITIES AND A METHOD OF PREPARING THE SAME | HASPIN, GGPS1, GNA15 | CASP3 1317/4885CES1 773/4885TTR 4315/4885 |
| US-20160185771-A1 | Conjugate of Benzofuranone and Indole or Azaindole, and Preparation and Uses Thereof | INMT, KMO, IDO1 | CASP3 976/4885CES1 2095/4885TTR 1907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.