Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 2/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24790325 | 0.87 | DRD2 (0.39) | DRD4CACNA1IIKZF2CCR5 | |
| SCHEMBL24790866 | 0.86 | DRD2 (0.39) | ALDH1A1CCR5 | |
| SCHEMBL25618774 | 0.80 | IKZF2 (0.32) | IKZF2 | |
| SCHEMBL25619901 | 0.80 | IKZF1 (0.35) | DRD4KMT2ACXCR4PARP1PARP2 | |
| SCHEMBL24789054 | 0.79 | DRD4 (0.32) | DRD4 | |
| SCHEMBL24790237 | 0.79 | HRH3 (0.37) | DRD4NAMPT | |
| SCHEMBL25625115 | 0.78 | AKT1 (0.36) | KMT2ACCR5 | |
| SCHEMBL24790326 | 0.78 | IKZF1 (0.43) | KDM4ESIGMAR1KMT2AIKZF2ALDH1A1 | |
| SCHEMBL25996614 | 0.77 | IKZF2 (0.33) | KDM4EIKZF2ALDH1A1NAMPT | |
| SCHEMBL24790875 | 0.76 | PRKAA2 (0.35) | TLR9TLR7CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3672949-B1 | 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2022-12-21 | — | — | EP | disclosed |