Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | COMT | P21964 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21470789 | 0.80 | MGAM (0.31) | GAA | |
| SCHEMBL24797975 | 0.76 | ELANE (0.47) | KDM4ELMNAMAPTTSHRMEN1 | |
| SCHEMBL24798220 | 0.74 | MEN1 (0.30) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL24797980 | 0.72 | BRD4 (0.34) | GAAL3MBTL1 | |
| SCHEMBL20439496 | 0.72 | XDH (0.31) | — | |
| SCHEMBL20488209 | 0.72 | L3MBTL1 (0.55) | KDM4EHTTL3MBTL1PTGDR2 | |
| SCHEMBL19937802 | 0.71 | ALDH1A1 (0.34) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL6909950 | 0.70 | KDM4E (0.46) | KDM4ELMNAMAPTTP53TSHR | |
| SCHEMBL24799242 | 0.68 | PTGS2 (0.32) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6910469 | 0.67 | MAPT (0.44) | KDM4ELMNAMAPTTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3589618-B1 | PYRAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2022-12-28 | — | — | EP | disclosed |