Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.36 |
| ▸ | RPA1 | P27694 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.35 |
| ▸ | KMO | O15229 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | ARNT | P27540 | 3/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14735844 | 0.87 | XDH (0.35) | PTGS2RPA1SLC9A1CHRM3CHRM2 | |
| SCHEMBL2506075 | 0.86 | CNR2 (0.39) | ARNTEPAS1 | |
| SCHEMBL2482567 | 0.85 | MAPK14 (0.38) | PTGS2ABL1CHRM3CHRM2CHRM1 | |
| SCHEMBL422068 | 0.82 | MAPK14 (0.50) | PTGS2RPA1SLC9A1KMOPTGS1 | |
| SCHEMBL8236345 | 0.77 | KMO (0.38) | PTGS2RPA1KMOABL1PTGS1 | |
| SCHEMBL421904 | 0.76 | MAPK14 (0.56) | PTGS2CHRM3CHRM2CHRM1PTGS1 | |
| SCHEMBL2486902 | 0.74 | RPA1 (0.41) | PTGS2RPA1KMOCHRM3CHRM2 | |
| SCHEMBL2510401 | 0.74 | PGR (0.40) | CHRM3CHRM2CHRM1ARNTEPAS1 | |
| SCHEMBL2509882 | 0.73 | S1PR1 (0.36) | CHRM3ARNTEPAS1 | |
| SCHEMBL12942058 | 0.71 | KMO (0.43) | RPA1KMOABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376482-B1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AICURIS GMBH & CO KG (DE) | 2013-03-06 | — | — | EP | disclosed |
| EP-2376482-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010075962-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2010-07-08 | — | — | WO | disclosed |