Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | SORD | Q00796 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30856586 | 0.83 | HRH4 (0.39) | KMT2AMEN1HPGDNPSR1KDM4E | |
| SCHEMBL29195485 | 0.83 | HRH4 (0.39) | KMT2AMEN1HPGDNPSR1KDM4E | |
| SCHEMBL30788620 | 0.79 | HRH4 (0.58) | KMT2AMEN1HPGDNPSR1KDM4E | |
| SCHEMBL22148449 | 0.79 | HRH4 (0.58) | KMT2AMEN1HPGDNPSR1KDM4E | |
| SCHEMBL29195512 | 0.76 | GRIN2D (0.55) | KMT2AHPGDNPSR1KDM4EHSD17B10 | |
| SCHEMBL22119420 | 0.75 | NOS3 (0.44) | KMT2AMEN1HPGDNPSR1KDM4E | |
| SCHEMBL11898909 | 0.74 | KMT2A (0.68) | KMT2AMEN1NPSR1HSD17B10HRH4 | |
| SCHEMBL22155692 | 0.74 | KMT2A (0.42) | KMT2AMEN1HPGDNPSR1KDM4E | |
| SCHEMBL807735 | 0.72 | MEN1 (0.54) | KMT2AMEN1KDM4EUSP2HRH4 | |
| SCHEMBL31120933 | 0.71 | NOS3 (0.38) | KMT2AMEN1HPGDNPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117917405-A | KIF18A protein inhibitors | 杭州邦顺制药有限公司 | 2024-04-23 | — | — | CN | disclosed |
| WO-2022268230-A1 | COMPOUND AS KIF18A INHIBITOR | 杭州英创医药科技有限公司 | 2022-12-29 | — | — | WO | disclosed |