Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.52 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL107253 | 1.00 | TRPA1 (0.52) | TRPA1CSNK1ESIGMAR1HDAC3HDAC4 | |
| SCHEMBL5617449 | 1.00 | TRPA1 (0.52) | TRPA1CSNK1ESIGMAR1HDAC3HDAC4 | |
| SCHEMBL28192235 | 0.98 | TRPA1 (0.50) | TRPA1CSNK1ESIGMAR1HDAC3HDAC4 | |
| SCHEMBL10584313 | 0.89 | TRPA1 (0.43) | TRPA1CSNK1ESIGMAR1HDAC3HDAC4 | |
| SCHEMBL1828017 | 0.88 | CSNK1E (0.56) | TRPA1CSNK1ESIGMAR1SLC6A2TAAR1 | |
| Phthalic Acid SCHEMBL15388854 | 0.88 | ALDH1A1 (0.47) | TRPA1CSNK1EHDAC3HDAC4HDAC1 | |
| SCHEMBL5105980 | 0.86 | TRPA1 (0.52) | TRPA1SIGMAR1SLC6A2TAAR1MAOA | |
| SCHEMBL11334152 | 0.86 | CSNK1E (0.63) | TRPA1CSNK1E | |
| SCHEMBL28585706 | 0.86 | CSNK1E (0.63) | TRPA1CSNK1E | |
| SCHEMBL10497215 | 0.84 | CSNK1E (0.66) | TRPA1CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2377930-B1 | A group of esterases for the enantioselective production of fine and speciality chemicals | BRAIN BIOTECHNOLOGY RES & INFORMATION NETWORK AG (DE) | 2015-12-02 | — | — | EP | claimed |
| EP-2385109-B1 | A group of esterases for the enantioselective production of fine and speciality chemicals | BRAIN BIOTECHNOLOGY RES & INFORMATION NETWORK AG (DE) | 2015-12-02 | — | — | EP | claimed |
| EP-2013337-B1 | A GROUP OF ESTERASES FOR THE ENANTIOSELECTIVE PRODUCTION OF FINE AND SPECIALITY CHEMICALS | BRAIN BIOTECHNOLOGY RES & INFORMATION NETWORK AG (DE) | 2013-03-27 | — | — | EP | claimed |
| EP-2385109-A2 | A group of esterases for the enantioselective production of fine and speciality chemicals | B.R.A.I.N. Biotechnology Research And Information Network AG (DE) | 2011-11-09 | — | — | EP | claimed |
| EP-2377930-A1 | A group of esterases for the enantioselective production of fine and speciality chemicals | B.R.A.I.N. Biotechnology Research And Information Network AG (DE) | 2011-10-19 | — | — | EP | claimed |
| US-20090311745-A1 | GROUP OF ESTERASES FOR THE ENANTIOSELECTIVE PRODUCTION OF FINE AND SPECIALITY CHEMICALS | B.R.A.I.N AG (DE) | 2009-12-17 | — | — | US | claimed |
| EP-2013337-A2 | A GROUP OF ESTERASES FOR THE ENANTIOSELECTIVE PRODUCTION OF FINE AND SPECIALITY CHEMICALS | B.R.A.I.N. AG (DE) | 2009-01-14 | — | — | EP | claimed |
| WO-2007128496-A2 | A GROUP OF ESTERASES FOR THE ENANTIOSELECTIVE PRODUCTION OF FINE AND SPECIALITY CHEMICALS | B.R.A.I.N. AG (DE) | 2007-11-15 | — | — | WO | claimed |
| US-11767310-B2 | Nicotinamide RIPK1 inhibitors | ABBVIE INC. (US) | 2023-09-26 | — | — | US | disclosed |
| US-20230127127-A1 | NICOTINAMIDE RIPK1 INHIBITORS | ABBVIE INC. | 2023-04-27 | — | — | US | disclosed |
| US-20210198252-A1 | SMYD INHIBITORS | EPIZYME INC (US) | 2021-07-01 | — | — | US | disclosed |
| US-20190322660-A1 | SMYD INHIBITORS | Epizyme, Inc. | 2019-10-24 | — | — | US | disclosed |
| EP-2377930-B1 | A group of esterases for the enantioselective production of fine and speciality chemicals | BRAIN BIOTECHNOLOGY RES & INFORMATION NETWORK AG (DE) | 2015-12-02 | — | — | EP | disclosed |
| EP-2385109-B1 | A group of esterases for the enantioselective production of fine and speciality chemicals | BRAIN BIOTECHNOLOGY RES & INFORMATION NETWORK AG (DE) | 2015-12-02 | — | — | EP | disclosed |
| WO-2007128496-A2 | A GROUP OF ESTERASES FOR THE ENANTIOSELECTIVE PRODUCTION OF FINE AND SPECIALITY CHEMICALS | B.R.A.I.N. AG (DE) | 2007-11-15 | — | — | WO | disclosed |
| EP-1847533-A1 | SIX-MEMBERED HETEROCYCLIC COMPOUND AND THE USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2007-10-24 | — | — | EP | disclosed |
| US-7229817-B2 | Recombinant porcine liver esterases, their use and a method for the production thereof | DEGUSSA AG (DE) | 2007-06-12 | — | — | US | disclosed |
| US-20040161836-A1 | Recombinant porcine liver esterases, their use and a method for the production thereof | ENZYMICALS AG (DE) | 2004-08-19 | — | — | US | disclosed |
| EP-1343902-A2 | RECOMBINANT PORCINE LIVER ESTERASES, THEIR USE AND A METHOD FOR THE PRODUCTION THEREOF | Degussa AG (DE) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002048322-A2 | RECOMBINANT PORCINE LIVER ESTERASES, THEIR USE AND A METHOD FOR THE PRODUCTION THEREOF | DEGUSSA AG (DE) | 2002-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230127127-A1 | NICOTINAMIDE RIPK1 INHIBITORS | RIPK1, RIPK2, RIPK4 | TRPA1 4540/4885CSNK1E 654/4885SIGMAR1 4605/4885 |
| US-11767310-B2 | Nicotinamide RIPK1 inhibitors | RIPK1, RIPK2, RIPK4 | TRPA1 4540/4885CSNK1E 654/4885SIGMAR1 4605/4885 |
| US-20210198252-A1 | SMYD INHIBITORS | SMYD3, SMYD2, SMURF2 | TRPA1 4408/4885CSNK1E 1133/4885SIGMAR1 1193/4885 |
| US-20190322660-A1 | SMYD INHIBITORS | SMYD2, SMYD3, SMURF2 | TRPA1 4192/4885CSNK1E 981/4885SIGMAR1 546/4885 |
| US-20040161836-A1 | Recombinant porcine liver esterases, their use and a method for the production thereof | CES1, PIGS, BCHE | TRPA1 4365/4885CSNK1E 1015/4885SIGMAR1 2950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.