SCHEMBL24818812

SCHEMBL24818812

Cn1cnnc1-c1cc(C#N)ccc1-c1cccc(-c2nc3cccc(C(F)(F)F)c3o2)c1

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 4/20 0.39
▸ FNTA P49354 6/20 0.35
▸ FNTB P49356 6/20 0.35
▸ NSD2 O96028 1/20 0.34
▸ CETP P11597 5/20 0.34
▸ NOTUM Q6P988 1/20 0.33
▸ ACP1 P24666 1/20 0.33
▸ ELANE P08246 1/20 0.33
▸ VSIR Q9H7M9 1/20 0.33
▸ CBL P22681 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30153053 1.00 CBLB (0.39) CBLBFNTAFNTBNSD2CETP
SCHEMBL30153241 0.88 CBLB (0.39) CBLBFNTAFNTBCETPNOTUM
SCHEMBL30152890 0.88 CBLB (0.40) CBLBFNTAFNTBNSD2CETP
SCHEMBL24818896 0.88 CBLB (0.40) CBLBFNTAFNTBNSD2CETP
SCHEMBL24818899 0.88 CBLB (0.39) CBLBFNTAFNTBCETPNOTUM
SCHEMBL24819899 0.88 CBLB (0.39) CBLBVSIR
SCHEMBL30152749 0.87 CBLB (0.43) CBLBNOTUMVSIR
SCHEMBL24819869 0.87 CBLB (0.43) CBLBNOTUMVSIR
SCHEMBL24818895 0.84 CBLB (0.38) CBLBFNTAFNTBNSD2CETP
SCHEMBL30153123 0.84 CBLB (0.38) CBLBFNTAFNTBNSD2CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117858865-A CBL-B modulators and uses thereof 林伯士克莱奥公司 2024-04-09 — — CN disclosed
WO-2022272248-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2022-12-29 — — WO disclosed
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