Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 3/20 | 0.39 |
| ▸ | VSIR | Q9H7M9 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30152749 | 0.91 | CBLB (0.43) | CBLBVSIRHSD11B1SCN9ATP53 | |
| SCHEMBL24819869 | 0.91 | CBLB (0.43) | CBLBVSIRHSD11B1SCN9ATP53 | |
| SCHEMBL24818951 | 0.89 | ESR2 (0.34) | CBLBVSIRHSD11B1P2RX7SCN9A | |
| SCHEMBL30153245 | 0.89 | ESR2 (0.34) | CBLBVSIRHSD11B1P2RX7SCN9A | |
| SCHEMBL24818812 | 0.88 | CBLB (0.39) | CBLBVSIR | |
| SCHEMBL30153053 | 0.88 | CBLB (0.39) | CBLBVSIR | |
| SCHEMBL24819724 | 0.87 | VSIR (0.33) | CBLBVSIRHSD11B1P2RX7HPGD | |
| SCHEMBL24818892 | 0.87 | VSIR (0.36) | CBLBVSIRP2RX7SCN9AHPGD | |
| SCHEMBL24818674 | 0.87 | VSIR (0.40) | CBLBVSIRP2RX7HPGDS1PR1 | |
| SCHEMBL24819864 | 0.87 | CETP (0.37) | CBLBVSIRHSD11B1P2RX7SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-117858865-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |