Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VSIR | Q9H7M9 | 6/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 2/20 | 0.34 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24820049 | 0.90 | VSIR (0.42) | VSIRPDCD1CD274HPGDMAPT | |
| SCHEMBL30153065 | 0.90 | VSIR (0.42) | VSIRESR1ESR2PDCD1CD274 | |
| SCHEMBL24821901 | 0.90 | VSIR (0.42) | VSIRESR1ESR2PDCD1CD274 | |
| SCHEMBL30153044 | 0.88 | VSIR (0.41) | VSIRPDCD1CD274HPGDMAPT | |
| SCHEMBL30152561 | 0.88 | VSIR (0.42) | VSIRESR1ESR2PDCD1CD274 | |
| SCHEMBL24820720 | 0.88 | VSIR (0.41) | VSIRPDCD1CD274HPGDMAPT | |
| SCHEMBL24819923 | 0.88 | VSIR (0.42) | VSIRESR1ESR2PDCD1CD274 | |
| SCHEMBL30153006 | 0.88 | VSIR (0.41) | VSIRPDCD1CD274 | |
| SCHEMBL24818952 | 0.88 | VSIR (0.41) | VSIRPDCD1CD274 | |
| SCHEMBL24818912 | 0.87 | VSIR (0.39) | VSIRS1PR1ESR1ESR2PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-117858865-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |