Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | CASP3 | P42574 | 4/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CBLB | Q13191 | 1/20 | 0.32 |
| ▸ | AGPAT2 | O15120 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30153166 | 0.91 | CBLB (0.33) | CBLBF2RL3 | |
| SCHEMBL24818907 | 0.91 | CBLB (0.33) | CBLBF2RL3 | |
| SCHEMBL30153103 | 0.88 | CBLB (0.42) | CBLBCYP11B1 | |
| SCHEMBL24820565 | 0.88 | CBLB (0.42) | CBLBCYP11B1 | |
| SCHEMBL24820135 | 0.87 | CBLB (0.33) | CBLB | |
| SCHEMBL30152729 | 0.87 | CBLB (0.33) | CBLB | |
| SCHEMBL24820738 | 0.86 | NPC1 (0.35) | KDM4ESMN1; SMN2ALDH1A1HPGDLMNA | |
| SCHEMBL30792049 | 0.85 | AGPAT2 (0.38) | KDM4ESMN1; SMN2ALDH1A1HPGDNFKB1 | |
| SCHEMBL24820737 | 0.85 | AGPAT2 (0.38) | KDM4ESMN1; SMN2ALDH1A1HPGDNFKB1 | |
| SCHEMBL24820705 | 0.84 | CASP3 (0.42) | KDM4ESMN1; SMN2ALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-117858865-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |