Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | FLT4 | P35916 | 3/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.41 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL617215 | 0.79 | CSF1R (0.46) | CSF1RFLT4PDGFRAFLT3KCNH2 | |
| SCHEMBL253705 | 0.75 | AURKA (0.47) | AURKARPS6KB1AURKBGPR52 | |
| SCHEMBL252286 | 0.75 | PARP1 (0.41) | RPS6KB1CDK2 | |
| SCHEMBL248208 | 0.75 | TRPV1 (0.47) | CSF1RFLT4PDGFRAFLT3KCNH2 | |
| SCHEMBL253233 | 0.74 | SYK (0.40) | RPS6KB1GPR52 | |
| SCHEMBL253123 | 0.73 | SYK (0.42) | KCNH2GPR52NTRK1NTRK3 | |
| SCHEMBL619784 | 0.71 | TRPV1 (0.53) | TRPV1 | |
| SCHEMBL617313 | 0.71 | ENPP2 (0.46) | CSF1RFLT4PDGFRAFLT3KCNH2 | |
| SCHEMBL616887 | 0.70 | CSF1R (0.47) | CSF1RAURKARPS6KB1AURKBTRPV1 | |
| SCHEMBL619224 | 0.69 | TRPV1 (0.43) | CSF1RFLT4PDGFRAFLT3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401275-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | Respiratorius AB (SE) | 2012-01-04 | — | — | EP | disclosed |