Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.40 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.39 |
| ▸ | KLK8 | O60259 | 7/20 | 0.38 |
| ▸ | F2 | P00734 | 7/20 | 0.38 |
| ▸ | F10 | P00742 | 7/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 7/20 | 0.38 |
| ▸ | KLK14 | Q9P0G3 | 7/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 7/20 | 0.38 |
| ▸ | ST14 | Q9Y5Y6 | 7/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL619180 | 0.79 | HCRTR1 (0.44) | SYKLRRK2 | |
| SCHEMBL253123 | 0.79 | SYK (0.42) | SYKGPR52 | |
| SCHEMBL253705 | 0.77 | AURKA (0.47) | GPR52RPS6KB1 | |
| SCHEMBL253234 | 0.75 | PSMD14 (0.50) | LRRK2 | |
| SCHEMBL252708 | 0.75 | MKNK1 (0.48) | SYK | |
| SCHEMBL252286 | 0.75 | PARP1 (0.41) | PPARGPPARARPS6KB1 | |
| SCHEMBL249951 | 0.74 | CTSS (0.48) | CTSSLRRK2SRPK3KLK8F2 | |
| SCHEMBL248207 | 0.74 | CSF1R (0.43) | GPR52RPS6KB1 | |
| SCHEMBL2146575 | 0.69 | CTSS (0.49) | CTSSLRRK2MRGPRX4 | |
| SCHEMBL253870 | 0.68 | CYP11B1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401275-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | Respiratorius AB (SE) | 2012-01-04 | — | — | EP | claimed |
| EP-2401275-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | Respiratorius AB (SE) | 2012-01-04 | — | — | EP | disclosed |