Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2485825 | 0.92 | LMNA (0.47) | PDK1LMNAKMT2ASMN1; SMN2HTT | |
| SCHEMBL2487605 | 0.92 | PDK1 (0.42) | PDK1LMNAALDH1A1CLK1MAPK1 | |
| SCHEMBL416236 | 0.89 | CLK1 (0.49) | PDK1LMNAALDH1A1CLK1MAPK1 | |
| SCHEMBL417568 | 0.89 | RIPK1 (0.46) | PDK1LMNAALDH1A1CLK1KMT2A | |
| SCHEMBL416207 | 0.83 | MAPK1 (0.60) | LMNAALDH1A1MAPK1MAPTKMT2A | |
| SCHEMBL418540 | 0.83 | NPC1 (0.55) | ALDH1A1POLBKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL418243 | 0.82 | RIPK1 (0.49) | PDK1LMNAALDH1A1MAPTPOLB | |
| SCHEMBL2484074 | 0.82 | LMNA (0.47) | LMNAALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2482708 | 0.78 | TSHR (0.54) | LMNAALDH1A1MAPK1MAPTKMT2A | |
| SCHEMBL412372 | 0.78 | ALDH1A1 (0.53) | LMNAALDH1A1MAPK1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376431-A1 | NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS | LABORATOIRE BIODIM (FR) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010066847-A1 | NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS | CELLVIR (FR) | 2010-06-17 | — | — | WO | disclosed |