Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL418243 | 0.93 | RIPK1 (0.49) | LMNANPC1RAB9APKMKMT2A | |
| SCHEMBL2485786 | 0.91 | ALDH1A1 (0.45) | LMNANPC1RAB9APKMKMT2A | |
| SCHEMBL418467 | 0.86 | NPC1 (0.59) | NPC1RAB9AKMT2ASMN1; SMN2RIPK1 | |
| SCHEMBL2485825 | 0.85 | LMNA (0.47) | LMNANPC1RAB9APKMKMT2A | |
| SCHEMBL418472 | 0.84 | ALDH1A1 (0.50) | LMNANPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL2482403 | 0.82 | PDK1 (0.46) | LMNAKMT2ASMN1; SMN2HTTMAPT | |
| SCHEMBL2487605 | 0.82 | PDK1 (0.42) | LMNANPC1RAB9APKMKMT2A | |
| SCHEMBL416236 | 0.82 | CLK1 (0.49) | LMNAPKMKMT2ASMN1; SMN2HTT | |
| SCHEMBL417568 | 0.82 | RIPK1 (0.46) | LMNANPC1RAB9APKMKMT2A | |
| SCHEMBL10247697 | 0.79 | NPC1 (0.66) | NPC1RAB9AKMT2ASMN1; SMN2RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376431-A1 | NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS | LABORATOIRE BIODIM (FR) | 2011-10-19 | — | — | EP | claimed |
| WO-2010066847-A1 | NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS | CELLVIR (FR) | 2010-06-17 | — | — | WO | claimed |