SCHEMBL248270

SCHEMBL248270

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nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HSPD1 P10809 2/20 1.00
HSPE1 P61604 2/20 1.00
MEN1 O00255 2/20 0.86
KMT2A Q03164 2/20 0.86
USP2 O75604 1/20 0.86
ADORA3 P0DMS8 1/20 0.84
DRD1 P21728 1/20 0.84
NPC1 O15118 1/20 0.70
MTOR P42345 1/20 0.70
RAB9A P51151 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL248559 1.00 HSPD1 (1.00) HSPD1HSPE1MEN1KMT2AUSP2
SCHEMBL29523079 1.00 HSPD1 (1.00) HSPD1HSPE1MEN1KMT2AUSP2
SCHEMBL29355814 1.00 HSPD1 (1.00) HSPD1HSPE1MEN1KMT2AUSP2
SCHEMBL19708763 1.00 HSPD1 (1.00) HSPD1HSPE1MEN1KMT2AUSP2
Eprinomectin SCHEMBL29392105 0.99 HSPD1 (0.98) HSPD1HSPE1MEN1KMT2AUSP2
Eprinomectin SCHEMBL120548 0.99 HSPD1 (0.98) HSPD1HSPE1MEN1KMT2AUSP2
Propylene Glycol SCHEMBL9901967 0.97 HSPD1 (0.94) HSPD1HSPE1MEN1KMT2AUSP2
SCHEMBL13309158 0.96 HSPD1 (0.93) HSPD1HSPE1MEN1KMT2AUSP2
SCHEMBL19708888 0.96 HSPD1 (0.91) HSPD1HSPE1MEN1KMT2AUSP2
SCHEMBL3913613 0.96 HSPD1 (0.91) HSPD1HSPE1MEN1KMT2AUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12098009-B2 Stand alone dispensing pouch Boehringer Ingelheim Animal Health USA Inc. (US) 2024-09-24 US disclosed
US-11985976-B2 Mixture of mectins and pyrethroids and uses thereof VALENT BIOSCIENCES LLC (US) 2024-05-21 US disclosed
CN-115768263-A Mixtures of pyrethroids and rhzomorphs and use thereof 瓦伦特生物科学有限责任公司 2023-03-07 CN disclosed
US-11583545-B2 Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof Boehringer Ingelheim Animal Health USA Inc. (US) 2023-02-21 US disclosed
EP-3599855-B1 DELAYED RELEASE FEED-THROUGH VETERINARY COMPOSITIONS WITH OVICIDAL AND LARVICIDAL ACTIVITY AGAINST SUSCEPTIBLE AND RESISTANT STRAINS OF PARASITES IN RUMINANTS' FECES, USE OF THESE COMPOSITIONS, METHOD FOR DELAYING THE RELEASE OF THESE COMPOSITIONS Champion USA LLC (US) 2022-03-02 EP disclosed
WO-2021252584-A1 A MIXTURE OF PYRETHROIDS AND MECTINS AND USES THEREOF VALENT BIOSCIENCES LLC (US) 2021-12-16 WO disclosed
US-20210386065-A1 MIXTURE OF MECTINS AND PYRETHROIDS AND USES THEREOF VALENT BIOSCIENCES LLC 2021-12-16 US disclosed
EP-3220888-B1 EPRINOMECTIN PARENTERAL COMPOSITIONS CEVA SANTE ANIMALE (FR) 2021-10-27 EP disclosed
US-20210315678-A1 STAND ALONE DISPENSING POUCH Boehringer Ingelheim Animal Health USA Inc. (US) 2021-10-14 US disclosed
EP-3820401-A1 STAND ALONE DISPENSING POUCH Boehringer Ingelheim Animal Health USA Inc. (US) 2021-05-19 EP disclosed
EP-1834670-A2 Anthelmintic compositions containing combinations of avermectins or milbemycins with bis-aryl compounds Pfizer, Inc. (US) 2007-09-19 EP disclosed
US-20070042013-A1 Long acting injectable formulations MERIAL, INC. 2007-02-22 US disclosed
US-20060128641-A1 Levamisole, avermectins or similar in pyrrolidone solvent MERIAL LIMITED 2006-06-15 US disclosed
US-20060105969-A1 Anthelmintic compositions BRUCE CHRISTOPHER I 2006-05-18 US disclosed
EP-1551390-A1 LEVAMISOLE, AVERMECTINS OR SIMILAR IN PYRROLIDONE SOLVENT Ashmont Holdings Limited (NZ) 2005-07-13 EP disclosed
US-20050118222-A1 Product to combat ticks and the process for the product's preparation WOLFF BRUCE ZBIG A (BR) 2005-06-02 US disclosed
WO-2004047795-A2 CUTANEOUS APPLICATION OF FLUPIRTINE BAYER HEALTHCARE AG (DE) 2004-06-10 WO disclosed
WO-2004009080-A1 Levamisole, Avermectins or similar in pyrrolidone solvent ASHMONT HOLDINGS LIMITED (NZ) 2004-01-29 WO disclosed
US-20030203859-A1 A combination of a bis-aryl compound (such as fipronil) and an avermectin or milbemycin or derivative useful as parasitic agent PFIZER INC. 2003-10-30 US disclosed
EP-1066854-A2 Anthelmintic compositions containing combinations of avermectins or milbemycins with bis-aryl compounds PFIZER INC. (US) 2001-01-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210386065-A1 MIXTURE OF MECTINS AND PYRETHROIDS AND USES THEREOF ACHE, DDT, PTMS HSPD1 1466/4885HSPE1 1503/4885MEN1 58/4885
US-20070042013-A1 Long acting injectable formulations LPXN, VIP, VEGFA HSPD1 4240/4885HSPE1 4142/4885MEN1 2171/4885
US-11583545-B2 Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof EPHX1, GPX4, EPX HSPD1 1486/4885HSPE1 1182/4885MEN1 3217/4885
US-20060105969-A1 Anthelmintic compositions TUBB, TUBA3C, CYP51A1 HSPD1 376/4885HSPE1 314/4885MEN1 3412/4885
US-11985976-B2 Mixture of mectins and pyrethroids and uses thereof ACHE, DDT, PTMS HSPD1 1466/4885HSPE1 1503/4885MEN1 58/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.