Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 5/20 | 0.43 |
| ▸ | CA1 | P00915 | 5/20 | 0.43 |
| ▸ | CA2 | P00918 | 5/20 | 0.43 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL595040 | 0.91 | L3MBTL1 (0.44) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL594740 | 0.78 | EGFR (0.42) | HDAC1FAAHMAPTMEN1KMT2A | |
| SCHEMBL595157 | 0.76 | CA12 (0.41) | CA12CA1CA2CA9MAPT | |
| SCHEMBL23462113 | 0.76 | L3MBTL1 (0.54) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL2483992 | 0.76 | ALDH1A1 (0.53) | L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL11904717 | 0.75 | ALDH1A1 (0.52) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL13283942 | 0.75 | PPARG (0.45) | L3MBTL1HDAC1MAPTTDP1RECQL | |
| SCHEMBL10227120 | 0.75 | FAAH (0.64) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL595225 | 0.75 | CA12 (0.52) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL594528 | 0.74 | FAAH (0.50) | L3MBTL1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376085-A1 | COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010080478-A1 | COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-07-15 | — | — | WO | disclosed |