Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL594987 | 0.86 | MAPT (0.54) | ALDH1A1PKMPOLBCASP6MEN1 | |
| SCHEMBL594717 | 0.82 | MAPT (0.49) | ALDH1A1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL594740 | 0.77 | EGFR (0.42) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL2483197 | 0.76 | L3MBTL1 (0.45) | MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL15270753 | 0.73 | KDM4E (0.47) | ALDH1A1POLBRAB9AMAPTL3MBTL1 | |
| SCHEMBL15484979 | 0.71 | KMT2A (0.44) | ALDH1A1PKMPOLBMEN1KMT2A | |
| SCHEMBL716542 | 0.70 | MAPT (0.50) | ALDH1A1MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL23271967 | 0.69 | KCNA3 (0.63) | ALDH1A1PKMMEN1KMT2ARAB9A | |
| SCHEMBL30003049 | 0.69 | KCNA3 (0.63) | ALDH1A1PKMMEN1KMT2ARAB9A | |
| SCHEMBL2452436 | 0.69 | ALDH1A1 (1.00) | ALDH1A1PKMPOLBCASP6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376085-A1 | COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010080478-A1 | COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-07-15 | — | — | WO | disclosed |