2-Picolinic Acid

2-Picolinic Acid

SCHEMBL2483447

O=C([O-])c1ccccn1.O=C([O-])c1ccccn1.[V+2]

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.64
CES1 P23141 1/20 0.64
L3MBTL1 Q9Y468 3/20 0.61
LMNA P02545 3/20 0.61
P4HTM Q9NXG6 2/20 0.61
NAPRT Q6XQN6 1/20 0.61
ALDH1A1 P00352 1/20 0.59
KMT2A Q03164 1/20 0.55
GSK3B P49841 1/20 0.53
KDM4E B2RXH2 3/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
MAPT P10636 1/20 0.47
PKM P14618 1/20 0.47
AGTR1 P30556 1/20 0.46
HDAC3 O15379 1/20 0.46
HDAC4 P56524 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC7 Q8WUI4 1/20 0.46
HDAC2 Q92769 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Picolinic Acid SCHEMBL30414202 1.00 CES2 (0.64) CES2CES1L3MBTL1LMNAP4HTM
2-Picolinic Acid SCHEMBL11378795 0.98 CES2 (0.67) CES2CES1L3MBTL1LMNAP4HTM
2-Picolinic Acid SCHEMBL673572 0.95 CES2 (0.64) CES2CES1L3MBTL1LMNAP4HTM
2-Picolinic Acid SCHEMBL15271681 0.95 CES2 (0.64) CES2CES1L3MBTL1LMNAP4HTM
2-Picolinic Acid SCHEMBL11378797 0.95 CES2 (0.64) CES2CES1L3MBTL1LMNAP4HTM
2-Picolinic Acid SCHEMBL5354659 0.95 CES2 (0.64) CES2CES1L3MBTL1LMNAP4HTM
2-Picolinic Acid SCHEMBL6054281 0.95 CES2 (0.64) CES2CES1L3MBTL1LMNAP4HTM
2-Picolinic Acid SCHEMBL5058098 0.95 CES2 (0.64) CES2CES1L3MBTL1LMNAP4HTM
2-Picolinic Acid SCHEMBL524041 0.95 CES2 (0.64) CES2CES1L3MBTL1LMNAP4HTM
2-Picolinic Acid SCHEMBL432467 0.95 CES2 (0.64) CES2CES1L3MBTL1LMNAP4HTM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9468645-B2 Highly soluble purine bioactive compounds and compositions thereof ENERGY BEVERAGES LLC 2016-10-18 US disclosed
US-20150238494-A1 HIGHLY SOLUBLE PURINE BIOACTIVE COMPOUNDS AND COMPOSITIONS THEREOF ENERGY BEVERAGES LLC 2015-08-27 US disclosed
US-20150132440-A1 DIPEPTIDE AND TRIPEPTIDE COMPOSITIONS AND USES JHO INTELLECTUAL PROPERTY HOLDINGS, LLC 2015-05-14 US disclosed
US-20150050260-A1 PYRROLOQUINOLINE QUINONE BASED COMPOSITIONS AND USES JHO INTELLECTUAL PROPERTY HOLDINGS, LLC 2015-02-19 US disclosed
US-8445466-B2 Stable aqueous compositions comprising amide-protected bioactive creatine species and uses thereof ENERGY BEVERAGES LLC 2013-05-21 US disclosed
EP-2377578-A1 Stable aqueous compositions comprising amide-protected bioactive creatine species and uses thereof Owoc, John H. (US) 2011-10-19 EP disclosed
US-20110251280-A1 Stable Aqueous Compositions Comprising Amide-Protected Bioactive Creatine Species and Uses Thereof ENERGY BEVERAGES LLC 2011-10-13 US disclosed
US-4731124-A Application technique for the descaling of surfaces CENTRAL ELECTRICITY GENERATING BOARD (GB) 1988-03-15 US disclosed
EP-0046029-B1 AN APPLICATION TECHNIQUE FOR THE DESCALING OF SURFACES CENTRAL ELECTRICITY GENERATING BOARD (GB) 1984-10-03 EP disclosed
US-4470951-A Application technique for the descaling of surfaces CENTRAL ELECTRICITY GENERATING BOARD (GB) 1984-09-11 US disclosed
EP-0046029-A1 An application technique for the descaling of surfaces CENTRAL ELECTRICITY GENERATING BOARD (GB) 1982-02-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110251280-A1 Stable Aqueous Compositions Comprising Amide-Protected Bioactive Creatine Species and Uses Thereof REN, CKMT1A; CKMT1B, GLS CES2 655/4885CES1 168/4885L3MBTL1 4591/4885
US-20150238494-A1 HIGHLY SOLUBLE PURINE BIOACTIVE COMPOUNDS AND COMPOSITIONS THEREOF ADORA2A, PNP, P2RX6 CES2 4668/4885CES1 3413/4885L3MBTL1 4314/4885
US-20150050260-A1 PYRROLOQUINOLINE QUINONE BASED COMPOSITIONS AND USES NQO1, NDUFB5, SDHA CES2 2371/4885CES1 1769/4885L3MBTL1 4820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.