Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.43 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL965090 | 1.00 | KDM4E (0.46) | KDM4EMAPK1SLC12A2SLC12A5HPGD | |
| SCHEMBL27206070 | 0.93 | KDM4E (0.39) | KDM4EMAPK1SLC12A2SLC12A5HPGD | |
| SCHEMBL537494 | 0.85 | KMT2A (0.38) | KDM4EMAPK1HPGDTSHRGAA | |
| SCHEMBL909752 | 0.85 | KMT2A (0.38) | KDM4EMAPK1HPGDTSHRGAA | |
| SCHEMBL909187 | 0.85 | KMT2A (0.38) | KDM4EMAPK1HPGDTSHRGAA | |
| SCHEMBL32681961 | 0.83 | SLC6A2 (0.37) | KDM4EMAPK1TSHRGAAPOLB | |
| SCHEMBL20184269 | 0.83 | ALDH1A1 (0.44) | KDM4EMAPK1MAPTGAAALDH1A1 | |
| SCHEMBL5153705 | 0.80 | ALDH1A1 (0.33) | KDM4EMAPK1HPGDTSHRGAA | |
| SCHEMBL23151908 | 0.80 | DRD4 (0.34) | KDM4EMAPK1PKMRAB9AHTT | |
| SCHEMBL20573229 | 0.79 | EPHX2 (0.38) | PKMRAB9ATSHRHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | NAVITOR PHARMACEUTICALS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. | 2021-08-05 | — | — | US | disclosed |
| EP-3292120-B1 | TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES AS INHIBITORS OF HBSAG (HBV SURFACE ANTIGEN) AND HBV DNA PRODUCTION FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTIONS | HOFFMANN LA ROCHE (CH) | 2019-06-19 | — | — | EP | disclosed |
| WO-2018191146-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-10-18 | — | — | WO | disclosed |
| US-8513162-B2 | Halogen-containing organosulfur compound and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-08-20 | — | — | US | disclosed |
| EP-2222165-B1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF | ABBVIE INC (US) | 2013-07-31 | — | — | EP | disclosed |
| US-20110257226-A1 | HALOGEN-CONTAINING ORGANOSULFUR COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-10-20 | — | — | US | disclosed |
| EP-2376450-A1 | HALOGEN-CONTAINING ORGANOSULFUR COMPOUNDS AND USE THEREOF FOR CONTROLLING ARTHROPOD PEST | Sumitomo Chemical Company, Limited (JP) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010074327-A1 | HALOGEN-CONTAINING ORGANOSULFUR COMPOUNDS AND USE THEREOF FOR CONTROLLING ARTHROPOD PEST | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-07-01 | — | — | WO | disclosed |
| EP-0608054-B1 | Catalyst compositions and process for preparing polyolefins | BP CHEM INT LTD (GB) | 1999-07-07 | — | — | EP | disclosed |
| US-5814574-A | ZIRCONIUM METALLOCENE POLYMERIZATION CATALYSTS; NARROW MOLECULAR WEIGHT DISTRIBUTION | BP CHEMICALS LIMITED (GB) | 1998-09-29 | — | — | US | disclosed |
| US-5767209-A | A METALLOCENE COMPLEX OF A GROUP 4 METAL AND A CYCLOPENTADIENYL NUCLEUS ON AN INORGANIC SUPPORT WITHOUT USING COCATALYSTS, E.G. ALUMOXANES, AS THE MEANS OF SUPPORT | BP CHEMICALS LIMITED (GB) | 1998-06-16 | — | — | US | disclosed |
| EP-0608054-A2 | Catalyst compositions and process for preparing polyolefins | BP Chemicals Limited (GB) | 1994-07-27 | — | — | EP | disclosed |
| US-4242343-A | TRANQUILIZERS, ANTIDEPRESSANTS | SYNTHELABO (FR) | 1980-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | RHEB, KRAS, NRAS | KDM4E 2462/4885MAPK1 3950/4885SLC12A2 4455/4885 |
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | RHEB, GDI2, KRAS | KDM4E 3566/4885MAPK1 3449/4885SLC12A2 4250/4885 |
| US-20110257226-A1 | HALOGEN-CONTAINING ORGANOSULFUR COMPOUND AND USE THEREOF | C1S, C5, L3MBTL3 | KDM4E 3003/4885MAPK1 3116/4885SLC12A2 1685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.