Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.44 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL3181225 | 1.00 | USP2 (0.64) | USP2HTTMEN1THRBKMT2A | |
| Propylene Glycol SCHEMBL8641217 | 1.00 | USP2 (0.64) | USP2HTTMEN1THRBKMT2A | |
| Propylene Glycol SCHEMBL5480105 | 1.00 | USP2 (0.64) | USP2HTTMEN1THRBKMT2A | |
| Propylene Glycol SCHEMBL8646850 | 1.00 | USP2 (0.64) | USP2HTTMEN1THRBKMT2A | |
| Propylene Glycol SCHEMBL669850 | 1.00 | USP2 (0.64) | USP2HTTMEN1THRBKMT2A | |
| Propylene Glycol SCHEMBL2770664 | 1.00 | USP2 (0.64) | USP2HTTMEN1THRBKMT2A | |
| Propylene Glycol SCHEMBL9070382 | 1.00 | USP2 (0.64) | USP2HTTMEN1THRBKMT2A | |
| Propylene Glycol SCHEMBL8644290 | 1.00 | USP2 (0.64) | USP2HTTMEN1THRBKMT2A | |
| Propylene Glycol SCHEMBL5469158 | 1.00 | USP2 (0.64) | USP2HTTMEN1THRBKMT2A | |
| Propylene Glycol SCHEMBL706277 | 1.00 | USP2 (0.64) | USP2HTTMEN1THRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110882181-B | Retinol oil composition | 强生消费者公司 | 2024-05-10 | — | — | CN | claimed |
| CN-115725241-B | Polysilicon polishing composition and application thereof | 万华化学集团电子材料有限公司 | 2024-05-03 | — | — | CN | claimed |
| CN-115725241-A | Polysilicon polishing composition and application thereof | 万华化学集团电子材料有限公司 | 2023-03-03 | — | — | CN | claimed |
| EP-3620213-B1 | RETINOL OIL COMPOSITION | JOHNSON & JOHNSON CONSUMER INC (US) | 2021-03-03 | — | — | EP | claimed |
| WO-2020112338-A1 | LUBRICATING OIL COMPOSITIONS WITH IMPROVED DEPOSIT RESISTANCE AND METHODS THEREOF | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2020-06-04 | — | — | WO | claimed |
| US-20200165537-A1 | LUBRICATING OIL COMPOSITIONS WITH IMPROVED DEPOSIT RESISTANCE AND METHODS THEREOF | EXXONMOBIL RES & ENG CO (US) | 2020-05-28 | — | — | US | claimed |
| US-10660866-B2 | Retinol oil composition | JOHNSON & JOHNSON CONSUMER INC. (US) | 2020-05-26 | — | — | US | claimed |
| CN-110882181-A | Retinol oil compositions | 强生消费者公司 | 2020-03-17 | — | — | CN | claimed |
| US-20200078317-A1 | RETINOL OIL COMPOSITION | KENVUE BRANDS LLC | 2020-03-12 | — | — | US | claimed |
| EP-3620213-A1 | RETINOL OIL COMPOSITION | JOHNSON & JOHNSON CONSUMER INC. (US) | 2020-03-11 | — | — | EP | claimed |
| CN-106999446-A | Oxapigenin patch | 纽罗德姆有限公司 | 2017-08-01 | — | — | CN | claimed |
| US-9387160-B2 | Composition and method of treating skin conditions | JOHNSON & JOHNSON CONSUMER HOLDINGS FRANCE (FR) | 2016-07-12 | — | — | US | claimed |
| EP-2376198-A2 | A COMPOSITION COMPRISING A RETINOID AND METHOD OF TREATING SKIN CONDITIONS | Johnson & Johnson Consumer Holdings France (FR) | 2011-10-19 | — | — | EP | claimed |
| US-20110251273-A1 | COMPOSITION AND METHOD OF TREATING SKIN CONDITIONS | KENVUE HOLDINGS FRANCE (FR) | 2011-10-13 | — | — | US | claimed |
| WO-2010072787-A2 | A COMPOSITION AND METHOD OF TREATING SKIN CONDITIONS. | JOHNSON & JOHNSON CONSUMER FRANCE SAS (FR) | 2010-07-01 | — | — | WO | claimed |
| EP-3381437-B1 | TOPICAL COMPOSITIONS COMPRISING RETINOIDS AND LOW IRRITATION POLYMERIC CLEANSING AGENTS | KENVUE BRANDS LLC (US) | 2024-12-18 | — | — | EP | disclosed |
| US-12036312-B2 | Non-aqueous topical compositions comprising a halogenated salicylanilide | UNION therapeutics A/S (DK) | 2024-07-16 | — | — | US | disclosed |
| US-20110251273-A1 | COMPOSITION AND METHOD OF TREATING SKIN CONDITIONS | KENVUE HOLDINGS FRANCE (FR) | 2011-10-13 | — | — | US | disclosed |
| WO-2010072787-A2 | A COMPOSITION AND METHOD OF TREATING SKIN CONDITIONS. | JOHNSON & JOHNSON CONSUMER FRANCE SAS (FR) | 2010-07-01 | — | — | WO | disclosed |
| CN-101090630-A | Formulations containing insect repellent compounds | DU PONT (US) | 2007-12-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200078317-A1 | RETINOL OIL COMPOSITION | RBP4, RBP1, LRAT | USP2 3899/4885HTT 4155/4885MEN1 4311/4885 |
| US-10660866-B2 | Retinol oil composition | RBP4, RBP1, LRAT | USP2 3899/4885HTT 4155/4885MEN1 4311/4885 |
| US-12036312-B2 | Non-aqueous topical compositions comprising a halogenated salicylanilide | CUTA, PTPN21, ABL2 | USP2 2509/4885HTT 2997/4885MEN1 4675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.