Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 15/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487142 | 0.89 | CHRM1 (0.48) | CHRM1NAMPTCHRM5 | |
| SCHEMBL2485727 | 0.89 | CHRM1 (0.60) | CHRM1NAMPTCHRM5CTSKCTSC | |
| SCHEMBL2489080 | 0.87 | CHRM1 (0.62) | CHRM1NAMPTCHRM5CTSKCTSC | |
| SCHEMBL2488682 | 0.84 | CHRM1 (0.57) | CHRM1CHRM5 | |
| SCHEMBL2489435 | 0.82 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL2488912 | 0.82 | ROCK2 (0.46) | CHRM1 | |
| SCHEMBL2486645 | 0.82 | CHRM1 (0.42) | CHRM1 | |
| SCHEMBL2491172 | 0.80 | CHRM1 (0.57) | CHRM1NAMPTCHRM5PRMT5WDR77 | |
| SCHEMBL3233811 | 0.79 | CHRM1 (0.47) | CHRM1 | |
| SCHEMBL2488401 | 0.79 | CHRM1 (0.62) | CHRM1CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |