Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2489433 | 0.89 | CHRM1 (0.56) | CHRM1MAPTFSCN1TP53RXFP1 | |
| SCHEMBL2488682 | 0.84 | CHRM1 (0.57) | CHRM1BDKRB1MAPTTP53RXFP1 | |
| SCHEMBL2485728 | 0.82 | CHRM1 (0.47) | CHRM1 | |
| SCHEMBL3233811 | 0.81 | CHRM1 (0.47) | CHRM1P2RX7PDE10AMAPTFSCN1 | |
| SCHEMBL2488912 | 0.81 | ROCK2 (0.46) | CHRM1 | |
| SCHEMBL2486645 | 0.80 | CHRM1 (0.42) | CHRM1PDE10ABDKRB1CTSA | |
| SCHEMBL2487142 | 0.80 | CHRM1 (0.48) | CHRM1MAPT | |
| SCHEMBL3234223 | 0.76 | CHRM1 (0.47) | CHRM1P2RX7PDE10AMAPTTP53 | |
| SCHEMBL3234555 | 0.76 | CHRM1 (0.49) | CHRM1P2RX7PDE10AMAPTTP53 | |
| SCHEMBL3228656 | 0.76 | CHRM1 (0.47) | CHRM1P2RX7MAPTTP53RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |