Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2485110 | 0.90 | CHRM1 (0.55) | CHRM1ERN1HSD17B1HSD17B2CNR2 | |
| SCHEMBL2488388 | 0.89 | CHRM1 (0.56) | CHRM1MCHR1EPHB4 | |
| SCHEMBL2491881 | 0.88 | ERN1 (0.42) | CHRM1ERN1F2RL3CNR2PIK3CA | |
| SCHEMBL2488682 | 0.86 | CHRM1 (0.57) | CHRM1BDKRB1 | |
| SCHEMBL2488912 | 0.83 | ROCK2 (0.46) | CHRM1 | |
| SCHEMBL3233811 | 0.82 | CHRM1 (0.47) | CHRM1PDE10A | |
| SCHEMBL2485728 | 0.82 | CHRM1 (0.47) | CHRM1 | |
| SCHEMBL2487142 | 0.81 | CHRM1 (0.48) | CHRM1PIK3CA | |
| SCHEMBL2489435 | 0.80 | CHRM1 (0.43) | CHRM1CTSAPDE10ABDKRB1 | |
| SCHEMBL2489082 | 0.80 | CHRM1 (0.45) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |