Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27608342 | 0.85 | ACHE (0.40) | SMN1; SMN2TSHRALDH1A1PTGS1HSD17B10 | |
| SCHEMBL29286690 | 0.84 | HTR1A (0.36) | SMN1; SMN2ALDH1A1PTGS1HSD17B10CFTR | |
| SCHEMBL27611466 | 0.82 | HTR1A (0.39) | SMN1; SMN2ALDH1A1PTGS1HSD17B10KDM4E | |
| SCHEMBL27747046 | 0.81 | NCEH1 (0.40) | SMN1; SMN2ALDH1A1PTGS1HSD17B10KDM4E | |
| SCHEMBL27641592 | 0.81 | HDAC1 (0.38) | ALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL27797978 | 0.81 | KEAP1 (0.40) | SMN1; SMN2ALDH1A1KDM4EACHELMNA | |
| SCHEMBL25295423 | 0.81 | ATM (0.42) | ALDH1A1PTGS1TDP1HSD17B10PGR | |
| SCHEMBL27529112 | 0.81 | MAPT (0.45) | ALDH1A1HSD17B10KDM4EGAAHPGD | |
| SCHEMBL29728939 | 0.80 | ALDH1A1 (0.59) | SMN1; SMN2TSHRALDH1A1PTGS1ADRA2B | |
| SCHEMBL11772785 | 0.80 | ALDH1A1 (0.59) | SMN1; SMN2TSHRALDH1A1PTGS1ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365571-A1 | COMPOUNDS AND COMPOSITIONS AS Sppl2a INHIBITORS | NOVARTIS AG (CH) | 2023-11-16 | — | — | US | disclosed |
| CN-104761507-B | Amido quinazoline derivatives and its application in drug | 广东东阳光药业有限公司 | 2019-11-12 | — | — | CN | disclosed |
| CN-105121415-B | Hdac inhibitor | 生物马林药物股份有限公司 | 2018-10-12 | — | — | CN | disclosed |
| CN-108290848-A | Super excellent oxidative catalyst based on macrocyclic compound | 卡内基美浓大学 | 2018-07-17 | — | — | CN | disclosed |
| CN-107922342-A | Histone deacetylase inhibitors | 生物马林药物股份有限公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-106458856-A | Inhibitors of histone lysine specific demethylase (lsd1) and histone deacetylases (hdacs) | 约翰霍普金斯大学 | 2017-02-22 | — | — | CN | disclosed |
| US-9266822-B2 | Solid forms of tacedinaline | THE BROAD INSTITUTE, INC. (US) | 2016-02-23 | — | — | US | disclosed |
| CN-105228609-A | New transcription factor regulator | CHEN LIN | 2016-01-06 | — | — | CN | disclosed |
| CN-105188371-A | Erk inhibitors and uses thereof | CELGENE AVILOMICS RES INC | 2015-12-23 | — | — | CN | disclosed |
| CN-105121415-A | Hdac inhibitors | BIOMARIN PHARM INC | 2015-12-02 | — | — | CN | disclosed |
| CN-1764648-A | Hydroxamic acid derivatives as inhibitors of Histone Deacetylase (HDAC) | FUJISAWA PHARMACEUTICAL CO (JP) | 2006-04-26 | — | — | CN | disclosed |
| CN-1747933-A | Novel monoacetyl o-phenylenediamine derivatives | HOFFMANN LA ROCHE (CH) | 2006-03-15 | — | — | CN | disclosed |
| CN-1723207-A | Histone deacetylase inhibitors | METHYLGENE INC (CA) | 2006-01-18 | — | — | CN | disclosed |
| CN-1705635-A | Inhibitors of histone deacetylase | METHYLGENE INC (CA) | 2005-12-07 | — | — | CN | disclosed |
| CN-1199954-C | Benzodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 2005-05-04 | — | — | CN | disclosed |
| CN-1195522-C | Benzodiazepine derivatives usable as parental metabolic glutamate receptor antagonist | HOFFMANN LA ROCHE (CH) | 2005-04-06 | — | — | CN | disclosed |
| CN-1578663-A | Histone deacetylase inhibitors | METHYLGENE INC (CA) | 2005-02-09 | — | — | CN | disclosed |
| CN-1535266-A | Dihydro-benzo [b][1,4] diazepin-2-one derivatives as mglur 2 antagonists II | - | 2004-10-06 | — | — | CN | disclosed |
| CN-1379764-A | Benzodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 2002-11-13 | — | — | CN | disclosed |
| CN-1379765-A | Benzodiazepine derivatives usable as parental metabolic glutamate receptor antagonist | HOFFMANN LA ROCHE (CH) | 2002-11-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365571-A1 | COMPOUNDS AND COMPOSITIONS AS Sppl2a INHIBITORS | SPPL2A, SPPL2B, BACE1 | SMN1; SMN2 2626/4885TSHR 4010/4885ALDH1A1 3565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.