Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | XPO1 | O14980 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2485581 | 0.83 | ALOX5 (0.47) | ALOX5MAPTTRPM8PTGESL3MBTL1 | |
| SCHEMBL2482216 | 0.82 | XPO1 (0.39) | ALOX5MAPTXPO1 | |
| SCHEMBL2483630 | 0.82 | KMO (0.39) | L3MBTL1SLC9A1CA12CA9GABRA2 | |
| SCHEMBL2487648 | 0.81 | ALOX5 (0.41) | ALOX5MAPTTRPM8PTGESL3MBTL1 | |
| SCHEMBL417516 | 0.81 | ALOX5 (0.49) | ALOX5MAPTTRPM8PTGESL3MBTL1 | |
| SCHEMBL2484620 | 0.79 | MAPT (0.46) | ALOX5MAPTTRPM8PTGESL3MBTL1 | |
| SCHEMBL2482550 | 0.76 | TRPM8 (0.46) | ALOX5MAPTTRPM8PTGESL3MBTL1 | |
| SCHEMBL2507675 | 0.73 | PGR (0.40) | ALOX5MAPTTRPM8KDM4EALDH1A1 | |
| SCHEMBL2486696 | 0.73 | CUL4A (0.47) | MAPTL3MBTL1KDM4EALDH1A1GAA | |
| SCHEMBL2485667 | 0.71 | TRPM8 (0.46) | ALOX5MAPTTRPM8PTGESL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376479-B1 | SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF | AICURIS GMBH & CO KG (DE) | 2016-03-02 | — | — | EP | disclosed |
| EP-2376479-A1 | SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010075957-A1 | SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2010-07-08 | — | — | WO | disclosed |