SCHEMBL24864837

SCHEMBL24864837

CN(C)CCn1c(=O)oc2ccc(Nc3ccc(N4CCC(C(F)(F)F)CC4)cc3)cc21

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
BCL6 P41182 1/20 0.38
SIGMAR1 Q99720 1/20 0.37
CNR2 P34972 1/20 0.36
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
CBX7 O95931 1/20 0.35
CDYL2 Q8N8U2 1/20 0.35
CDYL Q9Y232 1/20 0.35
CDY1; CDY1B Q9Y6F8 1/20 0.35
EGFR P00533 2/20 0.35
KMO O15229 1/20 0.35
SRC P12931 1/20 0.34
JAK2 O60674 1/20 0.34
CTSC P53634 1/20 0.34
HTR1A P08908 1/20 0.34
HTR7 P34969 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31123312 0.88 CNR2 (0.38) BCL6CNR2MEN1KMT2AEGFR
SCHEMBL29209022 0.88 CNR2 (0.38) BCL6CNR2MEN1KMT2AEGFR
SCHEMBL24865705 0.88 CNR2 (0.39) BCL6CNR2MEN1KMT2ACBX7
SCHEMBL24865368 0.87 EGFR (0.45) BCL6CNR2CBX7CDYL2CDYL
SCHEMBL24865798 0.86 HTR1A (0.38) BCL6MEN1KMT2AEGFRSRC
SCHEMBL24865740 0.85 BCL6 (0.40) BCL6CNR2MEN1KMT2A
SCHEMBL31123195 0.84 SLC6A2 (0.37) BCL6MEN1KMT2AEGFRHTR1A
SCHEMBL31123214 0.83 BCL6 (0.49) BCL6CNR2JAK2
SCHEMBL24865769 0.83 BCL6 (0.49) BCL6CNR2JAK2
SCHEMBL24864838 0.83 TP53 (0.40) BCL6CNR2MEN1KMT2AKMO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240327393-A1 FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2024-10-03 US disclosed
CN-117999259-A Iron death modulators, their preparation and use 维泰瑞隆有限公司 2024-05-07 CN disclosed
WO-2023280296-A1 FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2023-01-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240327393-A1 FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF AIFM2, GPX1, GPX4 BCL6 390/4885SIGMAR1 2490/4885CNR2 3115/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.