Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 15/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.40 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867299 | 0.90 | PDE4A (0.39) | CHEK1 | |
| SCHEMBL24867301 | 0.89 | PDE4A (0.38) | CHEK1 | |
| SCHEMBL24867187 | 0.79 | ACACB (0.38) | — | |
| SCHEMBL24867218 | 0.79 | OPRM1 (0.32) | — | |
| SCHEMBL24866872 | 0.77 | PTGS1 (0.45) | ROCK2ROCK1 | |
| SCHEMBL24866867 | 0.75 | PTGS1 (0.36) | — | |
| SCHEMBL24866869 | 0.74 | PDE4A (0.42) | — | |
| SCHEMBL24867304 | 0.72 | RAB9A (0.40) | — | |
| SCHEMBL24867298 | 0.72 | PTGS1 (0.38) | — | |
| SCHEMBL24867214 | 0.72 | RAB9A (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |