Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.60 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | FAAH | O00519 | 2/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 1/20 | 0.58 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.56 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.56 |
| ▸ | BCL2 | P10415 | 2/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27694888 | 0.90 | KMT2A (0.71) | RPA1MEN1KMT2AL3MBTL1CACNA1G | |
| SCHEMBL695352 | 0.87 | RPA1 (1.00) | RPA1MEN1KMT2AL3MBTL1CACNA1G | |
| SCHEMBL6341777 | 0.86 | CA9 (0.70) | — | |
| SCHEMBL9209551 | 0.85 | ALOX5 (0.60) | RPA1MEN1KMT2AL3MBTL1FAAH | |
| SCHEMBL22748927 | 0.84 | RPA1 (0.77) | RPA1MEN1KMT2AL3MBTL1CACNA1G | |
| Hydrochloric Acid SCHEMBL6315493 | 0.83 | RPA1 (0.65) | RPA1MEN1KMT2AL3MBTL1CACNA1G | |
| SCHEMBL16105107 | 0.82 | SLC5A1 (0.56) | RPA1CACNA1GCACNA1H | |
| SCHEMBL16105605 | 0.81 | FAAH (0.59) | RPA1FAAH | |
| Hydrochloric Acid SCHEMBL6315490 | 0.81 | RPA1 (0.62) | RPA1MEN1KMT2AL3MBTL1CACNA1G | |
| SCHEMBL16105650 | 0.80 | SLC5A1 (0.54) | RPA1CACNA1GCACNA1HFAAHCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066636-B1 | 5-PHENYL-NICOTINAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-1896445-B1 | ( 6-FLU0R0-BENZ0[l, 3] DIOXOLYL) -MORPHOLIN-4-YL-METHANONES AND THEIR USE AS CBl LIGANDS | HOFFMANN LA ROCHE (CH) | 2010-11-10 | — | — | EP | disclosed |
| US-7781593-B2 | CB1 cannabinoid receptor antagonists/inverse agonists; 5-(4-chloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(3-methoxy-propyl)-nicotinamide for example; eating disorders, obesity, diabetes type II or non insulin dependent diabetes (NIDD), neuroinflammation, diarrhea, drug abuse | HOFFMANN-LA ROCHE INC. (US) | 2010-08-24 | — | — | US | disclosed |
| US-20100056513-A1 | STEREOSPECIFICALLY SUBSTITUTED BENZO[1,3]DIOXOLYL DERIVATIVES | FREI BEAT | 2010-03-04 | — | — | US | disclosed |
| US-7629346-B2 | Pyrazinecarboxamide derivatives as CB1 antagonists | HOFFMANN-LA ROCHE INC. (US) | 2009-12-08 | — | — | US | disclosed |
| US-7579369-B2 | CB 1 receptor inverse agonists | HOFFMANN-LA ROCHE INC. (US) | 2009-08-25 | — | — | US | disclosed |
| EP-2035394-B1 | 2-PYRAZINECARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-08-19 | — | — | EP | disclosed |
| EP-1868999-B1 | PYRIDINE-3-CARBOXAMIDE DERIVATIVES AS CB1 INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |
| EP-2066636-A1 | 5-PHENYL-NICOTINAMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-06-10 | — | — | EP | disclosed |
| EP-2035394-A1 | 2-PYRAZINECARBOXAMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-03-18 | — | — | EP | disclosed |
| US-20060004055-A1 | Derivative of 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(piperidine-1-yl)-1H-pyrazole-3-carboxamide, the preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2006-01-05 | — | — | US | disclosed |
| EP-1583758-A1 | DERIVATIVE OF 5-(4-BROMOPHENYL)-1-(2,4-DICHLOROPHENLY)-4-ETHYL-N-(PIPERIDINE-1-YL)-1H-PYRAZOL-3-CARBOXAMIDE, THE PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2005-10-12 | — | — | EP | disclosed |
| US-6900227-B2 | Benzodioxole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2005-05-31 | — | — | US | disclosed |
| EP-1494673-A1 | COMPOUNDS HAVING UNIQUE CB1 RECEPTOR BINDING SELECTIVITY AND METHODS FOR THEIR PRODUCTION AND USE | RESEARCH TRIANGLE INSTITUTE (US) | 2005-01-12 | — | — | EP | disclosed |
| US-6825209-B2 | AN AMIDE DERIVATIVE USED AS CANNABINOID ANTAGONIST FOR THE TREATMENT OF OBESITY, SCHIZOPHRENIA, MEMORY DYSFUNCTION AND MARIJUANA ABUSE | RESEARCH TRIANGLE INSTITUTE | 2004-11-30 | — | — | US | disclosed |
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | HOFFMAN-LA ROCHE INC. | 2004-07-29 | — | — | US | disclosed |
| US-20040142922-A1 | Benzodioxole derivatives | HOFFMANN-LA ROCHE INC. | 2004-07-22 | — | — | US | disclosed |
| WO-2004058744-A1 | DERIVATIVE OF 5-(4-BROMOPHENYL)-1-(2,4-DICHLOROPHENLY)-4-ETHYL-N-(PIPERIDINE-1-YL)-1H-PYRAZOL-3-CARBOXAMIDE, THE PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2004-07-15 | — | — | WO | disclosed |
| WO-2003088968-A1 | COMPOUNDS HAVING UNIQUE CB1 RECEPTOR BINDING SELECTIVITY AND METHODS FOR THEIR PRODUCTION AND USE | RESEARCH TRIANGLE INSTITUTE (US) | 2003-10-30 | — | — | WO | disclosed |
| US-20030199536-A1 | Compounds having unique CB1 receptor binding selectivity and methods for their production and use | RESEARCH TRIANGLE INSTITUTE (US) | 2003-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199536-A1 | Compounds having unique CB1 receptor binding selectivity and methods for their production and use | CNR1, CNR2, GPR18 | RPA1 3340/4885MEN1 4450/4885KMT2A 1717/4885 |
| US-20060004055-A1 | Derivative of 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(piperidine-1-yl)-1H-pyrazole-3-carboxamide, the preparation and therapeutic use thereof | CYP11B2, CYP4B1, CYP3A5 | RPA1 4714/4885MEN1 2691/4885KMT2A 3157/4885 |
| US-20040142922-A1 | Benzodioxole derivatives | CNR1, CNR2, GPR119 | RPA1 4764/4885MEN1 2979/4885KMT2A 3559/4885 |
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | CNR1, CNR2, NPY1R | RPA1 4527/4885MEN1 2160/4885KMT2A 4280/4885 |
| US-20100056513-A1 | STEREOSPECIFICALLY SUBSTITUTED BENZO[1,3]DIOXOLYL DERIVATIVES | CNR1, CNR2, NPY1R | RPA1 4658/4885MEN1 1914/4885KMT2A 2820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.