Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 4/20 | 0.57 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.57 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.57 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.57 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16625049 | 0.93 | GABRA1 (0.51) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL6620532 | 0.81 | GABRA1 (0.39) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL12794057 | 0.80 | GABRA1 (0.48) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2653496 | 0.80 | GABRA1 (0.41) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2053509 | 0.76 | GABRG2 (0.42) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL29469733 | 0.73 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL249109 | 0.73 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL12794117 | 0.73 | GABRA1 (0.45) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL249110 | 0.72 | GABRG2 (0.58) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2654854 | 0.72 | GABRG2 (0.82) | GABRG2GABRB3GABRA3GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150111895-A1 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES | CONCERT PHARMACEUTICALS INC (US) | 2015-04-23 | — | — | US | disclosed |
| US-8921366-B2 | Substituted triazolo-pyridazine derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| EP-2328414-B1 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES | CONCERT PHARMACEUTICALS INC (US) | 2013-12-11 | — | — | EP | disclosed |
| US-20130225590-A1 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2013-08-29 | — | — | US | disclosed |
| US-8399467-B2 | Substituted triazolo-pyridazine derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-20120004236-A1 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2012-01-05 | — | — | US | disclosed |
| US-8003646-B2 | Substituted triazolo-pyridazine derivatives | CONCERT PHARMACEUTICALS INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-20100056529-A1 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2010-03-04 | — | — | US | disclosed |
| EP-1149102-B1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2004-12-08 | — | — | EP | disclosed |
| US-20030158203-A1 | Triazolo-pyridazine derivatives as ligands for GABA receptors | MERCK & CO., INC. | 2003-08-21 | — | — | US | disclosed |
| US-6500828-B1 | TREATMENT OF ANXIETY AND CONVULSIONS | MERCK SHARP & DOHME LTD. (GB) | 2002-12-31 | — | — | US | disclosed |
| EP-1149102-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000044752-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2000-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004236-A1 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES | GABRA5, GABRA2, GABRA3 | GABRG2 17/4885GABRB3 7/4885GABRA3 3/4885 |
| US-20150111895-A1 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES | GABRA5, GABRA2, GABRA3 | GABRG2 17/4885GABRB3 7/4885GABRA3 3/4885 |
| US-20100056529-A1 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES | GABRA5, GABRA2, GABRA3 | GABRG2 17/4885GABRB3 7/4885GABRA3 3/4885 |
| US-20030158203-A1 | Triazolo-pyridazine derivatives as ligands for GABA receptors | GABBR1, GABRA3, GABRA5 | GABRG2 15/4885GABRB3 8/4885GABRA3 2/4885 |
| US-20130225590-A1 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES | GABRA5, GABRA2, GABRA3 | GABRG2 17/4885GABRB3 7/4885GABRA3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.