Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | GRN | P28799 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27919008 | 0.88 | LMNA (0.41) | L3MBTL1SMN1; SMN2ALDH1A1HTTMAP4K4 | |
| SCHEMBL21188221 | 0.82 | SMN1; SMN2 (0.41) | L3MBTL1SMN1; SMN2ALDH1A1HTTMAP4K4 | |
| SCHEMBL3260918 | 0.82 | MKNK1 (0.42) | L3MBTL1SMN1; SMN2ALDH1A1HTTMAP4K4 | |
| SCHEMBL15671544 | 0.81 | SMN1; SMN2 (0.40) | L3MBTL1SMN1; SMN2ALDH1A1HTTMAP4K4 | |
| SCHEMBL11183659 | 0.79 | KDM4E (0.40) | L3MBTL1SMN1; SMN2ALDH1A1HTTMEN1 | |
| SCHEMBL27550332 | 0.79 | THRB (0.40) | L3MBTL1SMN1; SMN2ALDH1A1HTTMAP4K4 | |
| SCHEMBL27515772 | 0.79 | GRM5 (0.51) | L3MBTL1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL30210744 | 0.78 | HTT (0.46) | L3MBTL1SMN1; SMN2HTTKMT2A | |
| SCHEMBL10608717 | 0.78 | GABRA1 (0.36) | — | |
| Trifluoroacetic Acid SCHEMBL28546613 | 0.77 | MET (0.39) | L3MBTL1SMN1; SMN2ALDH1A1HTTMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635567-B1 | INDOLE DERIVATIVES | RICHTER GEDEON NYRT (HU) | 2015-10-28 | — | — | EP | claimed |
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |
| EP-0482349-A2 | Sulfonamides | BASF Aktiengesellschaft (DE) | 1992-04-29 | — | — | EP | disclosed |