Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL28546613 | 0.89 | MET (0.39) | MKNK1MKNK2MEN1KMT2AALDH1A1 | |
| SCHEMBL248731 | 0.82 | L3MBTL1 (0.39) | MKNK1MKNK2MEN1KMT2AALDH1A1 | |
| SCHEMBL27919008 | 0.82 | LMNA (0.41) | MKNK1MKNK2MEN1KMT2AALDH1A1 | |
| SCHEMBL21188221 | 0.81 | SMN1; SMN2 (0.41) | MKNK1MKNK2MEN1KMT2AALDH1A1 | |
| SCHEMBL15671544 | 0.79 | SMN1; SMN2 (0.40) | MKNK1MKNK2MEN1KMT2AALDH1A1 | |
| SCHEMBL11183659 | 0.78 | KDM4E (0.40) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL27550332 | 0.78 | THRB (0.40) | MKNK1MKNK2MEN1KMT2AALDH1A1 | |
| SCHEMBL11003322 | 0.78 | L3MBTL1 (0.53) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL11002480 | 0.77 | KMT2A (0.36) | MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL22723808 | 0.77 | PDK2 (0.45) | MKNK1MKNK2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112654605-B | Bridged heterocyclic group substituted pyrimidine compound and preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-112654605-A | Bridged heterocyclic group substituted pyrimidine compound and preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2021-04-13 | — | — | CN | disclosed |
| WO-2021027647-A1 | BRIDGED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 中国医药研究开发中心有限公司 | 2021-02-18 | — | — | WO | disclosed |
| CN-111954670-A | Sulfonylurea derivatives as NLRP3 inflammasome modulators | 诺瑟拉有限公司 | 2020-11-17 | — | — | CN | disclosed |
| CN-107207509-B | Substituted bridged ring urea analogs as sirtuin modulators | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2020-04-21 | — | — | CN | disclosed |
| CN-110627775-A | Small molecule compound | 嘉兴特科罗生物科技有限公司 | 2019-12-31 | — | — | CN | disclosed |
| WO-2014111871-A1 | 4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-07-24 | — | — | WO | disclosed |
| EP-2455098-A1 | New cyclic peptide compounds | Astellas Pharma Inc. (JP) | 2012-05-23 | — | — | EP | disclosed |
| EP-2150269-A1 | NEW CYCLIC PEPTIDE COMPOUNDS | Astellas Pharma Inc. (JP) | 2010-02-10 | — | — | EP | disclosed |
| WO-2009135865-A1 | PROCESS FOR THE PRODUCTION OF PARTICLES COMPRISING ACTIVE AGROCHEMICAL INGREDIENTS IN AMORPHOUS FORM | BASF SE (DE) | 2009-11-12 | — | — | WO | disclosed |
| WO-2008139986-A1 | NEW CYCLIC PEPTIDE COMPOUNDS | ASTELLAS PHARMA INC., (JP) | 2008-11-20 | — | — | WO | disclosed |
| US-4513000-A | Insecticidal N-substituted O-pyrazol-4-yl carbamates and use thereof | BAYER AKTIENGESELLSCHAFT (DE) | 1985-04-23 | — | — | US | disclosed |