Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31202474 | 1.00 | PTGS2 (0.53) | PTGS2CYP1A2CYP1A1CYP1B1NFE2L2 | |
| SCHEMBL248733 | 1.00 | PTGS2 (0.53) | PTGS2CYP1A2CYP1A1CYP1B1NFE2L2 | |
| Toluene SCHEMBL28179542 | 0.87 | NFE2L2 (0.54) | PTGS2CYP1A2CYP1A1CYP1B1NFE2L2 | |
| Toluene SCHEMBL28178698 | 0.87 | NFE2L2 (0.54) | PTGS2CYP1A2CYP1A1CYP1B1NFE2L2 | |
| SCHEMBL6821816 | 0.85 | PTPN11 (0.46) | CYP1A2MAOAMAOBCYP2C9 | |
| SCHEMBL13858839 | 0.85 | PYGL (0.45) | PTGS2CYP1A2HSD11B1MAOAMAOB | |
| SCHEMBL13858840 | 0.85 | PYGL (0.45) | PTGS2CYP1A2HSD11B1MAOAMAOB | |
| SCHEMBL6821813 | 0.85 | PTPN11 (0.46) | CYP1A2MAOAMAOBCYP2C9 | |
| SCHEMBL3572968 | 0.84 | HSD11B1 (0.61) | PTGS2CYP1A2CYP1A1CYP1B1NFE2L2 | |
| SCHEMBL3572966 | 0.84 | HSD11B1 (0.61) | PTGS2CYP1A2CYP1A1CYP1B1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110894184-B | Green and environment-friendly ticagrelor intermediate preparation method | 安徽一帆香料有限公司 | 2022-02-18 | — | — | CN | claimed |
| CN-110894184-A | Green and environment-friendly ticagrelor intermediate preparation method | 安徽一帆香料有限公司 | 2020-03-20 | — | — | CN | claimed |
| CN-107141236-B | The novel synthesis of ticagrelor midbody (1R, 2R) -2- (3,4- difluoro-benzene base) cyclopropane nitrile | 台州职业技术学院 | 2019-03-22 | — | — | CN | claimed |
| CN-107141236-A | The novel synthesis of ticagrelor midbody (1R, 2R) 2 (3,4 difluoro-benzene base) cyclopropane nitrile | 台州职业技术学院 | 2017-09-08 | — | — | CN | claimed |
| US-20120130097-A1 | PROCESS FOR THE PREPARATION OF CYCLOPROPYL CARBOXYLIC ACID ESTERS AND DERIVATIVES | ASTRAZENECA AB (SE) | 2012-05-24 | — | — | US | claimed |
| US-20110190520-A1 | Process for the preparation of cyclopropyl carboxylic acid esters and derivatives | ASTRAZENECA AB (SE) | 2011-08-04 | — | — | US | claimed |
| EP-2292591-A2 | Process for the preparation of cyclopropyl derivatives | AstraZeneca AB (SE) | 2011-03-09 | — | — | EP | claimed |
| EP-1760066-A2 | Processes for the preparation of cyclopropyl carboxylic acid derivatives and intermediates provided by these processes | AstraZeneca AB (SE) | 2007-03-07 | — | — | EP | claimed |
| US-20060258879-A1 | Process for the preparation of cyclopropyl carboxylic acid esters and derivatives | ASTRAZENECA AB (SE) | 2006-11-16 | — | — | US | claimed |
| JP-2003535072-A | — | — | 2003-11-25 | — | — | JP | claimed |
| US-20030120105-A1 | Process for the preparation of cyclopropyl carboxylic acid esters and derivatives | ASTRAZENECA AB (SE) | 2003-06-26 | — | — | US | claimed |
| EP-1292561-A1 | PROCESS FOR THE PREPARATION OF CYCLOPROPYL CARBOXYLIC ACID ESTERS AND DERIVATIVES | AstraZeneca AB (SE) | 2003-03-19 | — | — | EP | claimed |
| WO-2001092200-A1 | PROCESS FOR THE PREPARATION OF CYCLOPROPYL CARBOXYLIC ACID ESTERS AND DERIVATIVES | ASTRAZENECA AB (SE) | 2001-12-06 | — | — | WO | claimed |
| CN-115894496-A | Preparation method of ticagrelor and intermediate thereof | 上海贝美医药科技有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-110894184-B | Green and environment-friendly ticagrelor intermediate preparation method | 安徽一帆香料有限公司 | 2022-02-18 | — | — | CN | disclosed |
| CN-108329246-B | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as TRKA kinase inhibitors | 阵列生物制药公司 | 2021-02-26 | — | — | CN | disclosed |
| EP-1292561-A1 | PROCESS FOR THE PREPARATION OF CYCLOPROPYL CARBOXYLIC ACID ESTERS AND DERIVATIVES | AstraZeneca AB (SE) | 2003-03-19 | — | — | EP | disclosed |
| EP-1281726-A1 | Photo-alignment materials for liquid crystal alignment film | SAMSUNG ELECTRONICS CO LTD. (KR) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001092200-A1 | PROCESS FOR THE PREPARATION OF CYCLOPROPYL CARBOXYLIC ACID ESTERS AND DERIVATIVES | ASTRAZENECA AB (SE) | 2001-12-06 | — | — | WO | disclosed |
| WO-2001092263-A1 | NOVEL TRIAZOLO PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2001-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258879-A1 | Process for the preparation of cyclopropyl carboxylic acid esters and derivatives | MCCC2, DHPS, CYP3A4 | PTGS2 2872/4885CYP1A2 105/4885CYP1A1 188/4885 |
| US-20030120105-A1 | Process for the preparation of cyclopropyl carboxylic acid esters and derivatives | MCCC2, DHPS, CYP3A4 | PTGS2 2872/4885CYP1A2 105/4885CYP1A1 188/4885 |
| US-20110190520-A1 | Process for the preparation of cyclopropyl carboxylic acid esters and derivatives | MCCC2, DHPS, CYP3A4 | PTGS2 2872/4885CYP1A2 105/4885CYP1A1 188/4885 |
| US-20120130097-A1 | PROCESS FOR THE PREPARATION OF CYCLOPROPYL CARBOXYLIC ACID ESTERS AND DERIVATIVES | MCCC2, DHPS, CYP3A4 | PTGS2 2872/4885CYP1A2 105/4885CYP1A1 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.