Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CCNH | P51946 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31679800 | 1.00 | LMNA (0.58) | LMNATHRBPKMSLC22A12CDK1 | |
| SCHEMBL24876659 | 0.91 | LMNA (0.56) | LMNATHRBPKMSLC22A12BRD4 | |
| SCHEMBL31680011 | 0.91 | LMNA (0.56) | LMNATHRBPKMSLC22A12BRD4 | |
| SCHEMBL24876018 | 0.90 | LMNA (0.74) | LMNATHRBPKMCDK1CCNB1 | |
| SCHEMBL24876158 | 0.85 | THRB (0.56) | LMNATHRBPKMCDK1CCNB1 | |
| SCHEMBL31680049 | 0.85 | THRB (0.56) | LMNATHRBPKMCDK1CCNB1 | |
| SCHEMBL24876374 | 0.81 | LMNA (0.62) | LMNATHRBPKMBRD4KMT2A | |
| SCHEMBL31679967 | 0.80 | MAPT (0.52) | LMNATHRBPKMKMT2AMEN1 | |
| SCHEMBL24876314 | 0.80 | MAPT (0.52) | LMNATHRBPKMKMT2AMEN1 | |
| SCHEMBL31679837 | 0.79 | LMNA (0.58) | LMNATHRBPKMBRD4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023280970-A1 | INHIBITORS OF ALPHA-HEMOLYSIN OF STAPHYLOCOCCUS AUREUS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2023-01-12 | — | — | WO | disclosed |