Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 5/20 | 0.59 |
| ▸ | CTSL | P07711 | 5/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | MDH2 | P40926 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6434901 | 0.85 | KDM4E (0.48) | CTSVCTSLPOLBALDH1A1MAPT | |
| SCHEMBL256578 | 0.82 | CTSL (0.64) | CTSVCTSLPOLBALDH1A1MAPT | |
| SCHEMBL2063876 | 0.82 | CTSV (0.64) | CTSVCTSLPOLBALDH1A1MAPT | |
| SCHEMBL2063188 | 0.79 | CTSV (0.60) | CTSVCTSLPOLBALDH1A1MAPT | |
| SCHEMBL5458919 | 0.79 | CTSL (0.60) | CTSVCTSLPOLBALDH1A1MAPT | |
| SCHEMBL248837 | 0.78 | HTR1A (0.47) | CTSVCTSLPOLBALDH1A1MAPT | |
| SCHEMBL17067000 | 0.78 | CTSV (0.58) | CTSVCTSLPOLBALDH1A1MAPT | |
| SCHEMBL15730198 | 0.78 | CTSV (0.57) | CTSVCTSLPOLBALDH1A1MAPT | |
| SCHEMBL18474478 | 0.78 | CTSV (0.57) | CTSVCTSLPOLBALDH1A1MAPT | |
| SCHEMBL31756984 | 0.77 | MEN1 (0.56) | CTSVCTSLPOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170166567-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2017-06-15 | — | — | US | disclosed |
| US-20170166567-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2017-06-15 | — | — | US | disclosed |
| US-9598408-B2 | Imidazo[4,5-C]quinolines as DNA-PK inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2017-03-21 | — | — | US | disclosed |
| US-9598408-B2 | Imidazo[4,5-C]quinolines as DNA-PK inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2017-03-21 | — | — | US | disclosed |
| US-20150203491-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2015-07-23 | — | — | US | disclosed |
| US-20150203491-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2015-07-23 | — | — | US | disclosed |
| US-9000153-B2 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | MERCK PATENT GMBH (DE) | 2015-04-07 | — | — | US | disclosed |
| US-9000153-B2 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | MERCK PATENT GMBH (DE) | 2015-04-07 | — | — | US | disclosed |
| EP-2609082-B1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2015-02-18 | — | — | EP | disclosed |
| EP-2609082-B1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2015-02-18 | — | — | EP | disclosed |
| EP-2588457-B1 | PYRAZOLOQUINOLINE DERIVATIVES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2014-11-05 | — | — | EP | disclosed |
| US-8802712-B2 | Pyrazoloquinolines | MERCK PATENT GMBH (DE) | 2014-08-12 | — | — | US | disclosed |
| US-20130172337-A1 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-07-04 | — | — | US | disclosed |
| US-20130172337-A1 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-07-04 | — | — | US | disclosed |
| US-20130150359-A1 | PYRAZOLOQUINOLINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-06-13 | — | — | US | disclosed |
| EP-2588457-A1 | PYRAZOLO-QUINOLINES | Merck Patent GmbH (DE) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012000632-A1 | PYRAZOLO-QUINOLINES | MERCK PATENT GMBH (DE) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166567-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | CHEK1, CHEK2, TTK | CTSV 3875/4885CTSL 3397/4885POLB 280/4885 |
| US-20130172337-A1 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | CHEK1, CHEK2, TTK | CTSV 3875/4885CTSL 3397/4885POLB 280/4885 |
| US-20150203491-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | CHEK1, CHEK2, TTK | CTSV 3875/4885CTSL 3397/4885POLB 280/4885 |
| US-20130150359-A1 | PYRAZOLOQUINOLINES | PLK1, PKN3, PKN1 | CTSV 4055/4885CTSL 3804/4885POLB 1216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.