Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.64 |
| ▸ | CTSV | O60911 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MDH2 | P40926 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2063876 | 0.86 | CTSV (0.64) | CTSLCTSVPOLBHPGDSMN1; SMN2 | |
| SCHEMBL256579 | 0.83 | KDM4E (0.50) | CTSLCTSVPOLBHPGDSMN1; SMN2 | |
| SCHEMBL5458919 | 0.83 | CTSL (0.60) | CTSLCTSVPOLBHPGDSMN1; SMN2 | |
| SCHEMBL2063188 | 0.83 | CTSV (0.60) | CTSLCTSVPOLBHPGDSMN1; SMN2 | |
| SCHEMBL248836 | 0.82 | CTSV (0.59) | CTSLCTSVPOLBHPGDSMN1; SMN2 | |
| SCHEMBL17067000 | 0.81 | CTSV (0.58) | CTSLCTSVPOLBHPGDSMN1; SMN2 | |
| SCHEMBL15730198 | 0.81 | CTSV (0.57) | CTSLCTSVPOLBHPGDSMN1; SMN2 | |
| SCHEMBL18474478 | 0.81 | CTSV (0.57) | CTSLCTSVPOLBHPGDSMN1; SMN2 | |
| SCHEMBL18975225 | 0.81 | SRD5A1 (0.60) | CTSLCTSVPOLBHPGDSMN1; SMN2 | |
| SCHEMBL7823652 | 0.80 | CTSV (0.56) | CTSLCTSVPOLBHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028233-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |