Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2449767 | 0.89 | PTGS2 (0.35) | NPC1MAPTRAB9AALDH1A1HPGD | |
| SCHEMBL2449764 | 0.89 | PTGS2 (0.35) | NPC1MAPTRAB9AALDH1A1HPGD | |
| SCHEMBL2457235 | 0.84 | NPC1 (0.42) | NPC1MAPTRAB9AALDH1A1HPGD | |
| SCHEMBL2488367 | 0.80 | RAB9A (0.56) | NPC1MAPTRAB9AALDH1A1HPGD | |
| SCHEMBL2452091 | 0.79 | RAB9A (0.43) | NPC1MAPTRAB9AALDH1A1HPGD | |
| SCHEMBL13719230 | 0.77 | ALDH1A1 (0.46) | ALDH1A1FFAR1 | |
| SCHEMBL4575613 | 0.76 | SLC6A4 (0.48) | TSHRSLC6A4ST14HTR2A | |
| SCHEMBL2448201 | 0.74 | PTGS1 (0.39) | NPC1MAPTRAB9AALDH1A1HPGD | |
| SCHEMBL2449570 | 0.74 | MAPT (0.45) | NPC1MAPTRAB9AALDH1A1HPGD | |
| SCHEMBL2452036 | 0.73 | RAB9A (0.36) | NPC1MAPTRAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364088-A1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | Biogen Idec MA Inc. (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010051030-A1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | BIOGEN IDEC MA INC. (US) | 2010-05-06 | — | — | WO | disclosed |