Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487702 | 0.87 | LMNA (0.67) | LMNAMEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL2490511 | 0.85 | LMNA (0.59) | LMNACHRM1TP53CNR2 | |
| SCHEMBL3237179 | 0.81 | LMNA (0.59) | LMNACHRM1TP53CNR2 | |
| SCHEMBL3234156 | 0.81 | LMNA (0.62) | LMNACHRM1TP53CNR2 | |
| SCHEMBL2491002 | 0.79 | CHRM1 (0.71) | LMNAALDH1A1SMN1; SMN2CHRM1 | |
| SCHEMBL18672281 | 0.78 | ALDH1A1 (0.56) | LMNAMEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL3241260 | 0.77 | TP53 (0.68) | LMNAALDH1A1SMN1; SMN2CHRM1TP53 | |
| SCHEMBL8328934 | 0.76 | CHRM1 (0.47) | LMNACHRM1TP53F2RL3 | |
| SCHEMBL17943665 | 0.76 | ALDH1A1 (0.60) | LMNAMEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL2487409 | 0.75 | LMNA (0.47) | LMNACHRM1TP53CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |