Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ICMT | O60725 | 1/20 | 0.46 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329353 | 0.91 | ICMT (0.43) | CHRM1ICMTTP53 | |
| SCHEMBL8327498 | 0.90 | ICMT (0.45) | CHRM1POLBICMTF2RL3 | |
| SCHEMBL8329222 | 0.89 | ICMT (0.42) | CHRM1ICMTTP53 | |
| SCHEMBL8324163 | 0.89 | ICMT (0.45) | LMNAPOLBICMTF2RL3TP53 | |
| SCHEMBL8327081 | 0.86 | ICMT (0.43) | LMNAICMTTP53 | |
| SCHEMBL8327103 | 0.86 | ESR1 (0.40) | ICMTTP53 | |
| SCHEMBL8325939 | 0.85 | AGTR1 (0.57) | CHRM1LMNA | |
| SCHEMBL8322474 | 0.84 | AGTR1 (0.41) | POLBICMTF2RL3TP53 | |
| SCHEMBL8330654 | 0.84 | ICMT (0.40) | LMNAICMTTP53 | |
| SCHEMBL8325773 | 0.83 | AGTR1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498721-B1 | N-substituted quinoline derivatives, process for their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1999-12-22 | — | — | EP | claimed |