Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SDCBP | O00560 | 1/20 | 0.33 |
| ▸ | SDC2 | P34741 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24891481 | 0.85 | NAMPT (0.36) | THRBLMNAGAAPOLBMAPT | |
| SCHEMBL24790789 | 0.83 | IKZF2 (0.35) | THRBLMNAGAAPOLBMAPT | |
| SCHEMBL25626791 | 0.80 | DRD2 (0.42) | THRBLMNAMAPTSDCBPSDC2 | |
| SCHEMBL23482996 | 0.80 | SDCBP (0.42) | THRBGAAPOLBMAPTSDCBP | |
| SCHEMBL27320692 | 0.78 | NPC1 (0.42) | THRBLMNAGAAPOLBMAPT | |
| SCHEMBL21622035 | 0.78 | NPC1 (0.42) | THRBLMNAGAAPOLBMAPT | |
| SCHEMBL25032020 | 0.78 | ALOX15 (0.40) | THRBLMNAGAAPOLBMAPT | |
| SCHEMBL25993234 | 0.78 | THRB (0.44) | THRBLMNAGAAPOLBMAPT | |
| SCHEMBL24421564 | 0.77 | SDCBP (0.42) | THRBLMNAMAPTSDCBPSDC2 | |
| SCHEMBL24421543 | 0.77 | SDCBP (0.50) | THRBLMNAGAAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023288305-A1 | SMALL MOLECULE CYCLIN DEPENDENT KINASE 4/6 (CDK4/6) AND IKZF2 (HELIOS) DEGRADERS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-01-19 | — | — | WO | disclosed |