SCHEMBL2489854

SCHEMBL2489854

CCO[Si](C)(C)CCCSC(C)=O

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.35
POLB P06746 1/20 0.34
BLM P54132 1/20 0.34
ATM Q13315 1/20 0.34
HDAC3 O15379 1/20 0.30
HDAC4 P56524 1/20 0.30
HDAC1 Q13547 1/20 0.30
HDAC7 Q8WUI4 1/20 0.30
HDAC2 Q92769 1/20 0.30
HDAC10 Q969S8 1/20 0.30
HDAC11 Q96DB2 1/20 0.30
HDAC8 Q9BY41 1/20 0.30
HDAC6 Q9UBN7 1/20 0.30
HDAC9 Q9UKV0 1/20 0.30
HDAC5 Q9UQL6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28065159 0.89 CYP2C19 (0.38) CYP2C19POLBBLMATM
SCHEMBL19640254 0.85 CYP2C19 (0.35) CYP2C19POLBBLMATMHDAC3
SCHEMBL3680780 0.83 CYP2C19 (0.36) CYP2C19POLBBLMATMHDAC3
SCHEMBL15298634 0.81 CHRNB2 (0.39)
SCHEMBL2489412 0.78 CES2 (0.37) HDAC11
SCHEMBL29488592 0.77 CYP2C19 (0.32) CYP2C19POLBBLMATM
SCHEMBL19640265 0.77 CYP2C19 (0.38) CYP2C19POLBBLMATM
SCHEMBL28345659 0.76 HDAC3 (0.36) CYP2C19POLBBLMATMHDAC3
SCHEMBL4971701 0.76 HDAC3 (0.36) CYP2C19POLBBLMATMHDAC3
SCHEMBL27646679 0.76 HDAC3 (0.36) CYP2C19POLBBLMATMHDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9000092-B2 Rubber composition comprising a blocked mercaptosilane coupling agent COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2015-04-07 US disclosed
US-9000092-B2 Rubber composition comprising a blocked mercaptosilane coupling agent COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2015-04-07 US disclosed
US-20150005448-A1 RUBBER COMPOSITION COMPRISING A BLOCKED MERCAPTOSILANE COUPLING AGENT MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2015-01-01 US disclosed
US-20150005448-A1 RUBBER COMPOSITION COMPRISING A BLOCKED MERCAPTOSILANE COUPLING AGENT MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2015-01-01 US disclosed
EP-2791226-A1 RUBBER COMPOSITION COMPRISING A BLOCKED MERCAPTOSILANE COUPLING AGENT Compagnie Générale des Etablissements Michelin (FR) 2014-10-22 EP disclosed
EP-2379633-B1 RUBBER COMPOSITION COMPRISING A BLOCKED MERCAPTOSILANE COUPLING AGENT MICHELIN & CIE (FR) 2014-05-07 EP disclosed
WO-2013087693-A1 RUBBER COMPOSITION COMPRISING A BLOCKED MERCAPTOSILANE COUPLING AGENT COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2013-06-20 WO disclosed
WO-2013087693-A1 RUBBER COMPOSITION COMPRISING A BLOCKED MERCAPTOSILANE COUPLING AGENT COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2013-06-20 WO disclosed
US-20110306700-A1 RUBBER COMPOSITION COMPRISING A BLOCKED MERCAPTOSILANE COUPLING AGENT MICHELIN RECHERCHE ET TECHNIQUE S.A. (SE) 2011-12-15 US disclosed
EP-2379633-A1 RUBBER COMPOSITION COMPRISING A BLOCKED MERCAPTOSILANE COUPLING AGENT Société de Technologie MICHELIN (FR) 2011-10-26 EP disclosed
WO-2010072682-A1 RUBBER COMPOSITION COMPRISING A BLOCKED MERCAPTOSILANE COUPLING AGENT SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2010-07-01 WO disclosed
US-20100145089-A1 PREPARATION OF (POLY)SULFIDE ALKOXYSILANES AND NOVEL INTERMEDIATES THEREFOR RHODIA OPERATIONS (FR) 2010-06-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100145089-A1 PREPARATION OF (POLY)SULFIDE ALKOXYSILANES AND NOVEL INTERMEDIATES THEREFOR TST, CTH, CBS CYP2C19 3491/4885POLB 3097/4885BLM 1867/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.