Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22051445 | 0.77 | PDPK1 (0.52) | PDPK1LOXL2HSP90AA1CYP2A6HDAC2 | |
| SCHEMBL17275696 | 0.77 | TLR8 (0.58) | PDPK1LOXL2HSP90AA1CYP2A6DYRK1A | |
| SCHEMBL15668618 | 0.77 | PDPK1 (0.52) | PDPK1LOXL2HSP90AA1CYP2A6ADRB2 | |
| SCHEMBL1068648 | 0.77 | LOXL2 (0.55) | PDPK1LOXL2HSP90AA1CYP2A6HDAC2 | |
| SCHEMBL11013274 | 0.77 | PDPK1 (0.52) | PDPK1LOXL2HSP90AA1CYP2A6HDAC2 | |
| SCHEMBL4402187 | 0.76 | DYRK1A (0.63) | PDPK1DYRK1AMKNK1MKNK2NOS1 | |
| SCHEMBL30935767 | 0.76 | DYRK1A (0.63) | PDPK1DYRK1AMKNK1MKNK2NOS1 | |
| SCHEMBL30469264 | 0.76 | PDPK1 (0.60) | PDPK1LOXL2HSP90AA1CYP2A6HDAC2 | |
| SCHEMBL2315490 | 0.76 | PDPK1 (0.60) | PDPK1LOXL2HSP90AA1CYP2A6HDAC2 | |
| SCHEMBL15805858 | 0.75 | PDPK1 (0.72) | PDPK1LOXL2HSP90AA1CYP2A6HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109415358-B | 6-aminopyridin-3-ylthiazoles as ROR gamma t modulators | 詹森药业有限公司 | 2022-04-05 | — | — | CN | disclosed |
| EP-3448856-B1 | 6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF ROR GAMMA T | JANSSEN PHARMACEUTICA NV (BE) | 2022-01-05 | — | — | EP | disclosed |
| US-20210221804-A1 | 6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF RORyT | JANSSEN PHARMACEUTICA NV (BE) | 2021-07-22 | — | — | US | disclosed |
| US-20210198251-A1 | 6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF RORyT | JANSSEN PHARMACEUTICA NV (BE) | 2021-07-01 | — | — | US | disclosed |
| US-20210188836-A1 | 6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF RORyT | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-24 | — | — | US | disclosed |
| US-10975068-B2 | 6-aminopyridin-3-yl thiazoles as modulators of RORγT | JANSSEN PHARMACEUTICA NV (BE) | 2021-04-13 | — | — | US | disclosed |
| US-20170313691-A1 | 6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF RORyT | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-02 | — | — | US | disclosed |
| WO-2017189661-A1 | 6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF RORγT | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-02 | — | — | WO | disclosed |
| US-9198426-B2 | Use of 5 pyridin-4-yl-1,3-thiazoles for controlling phytopathogenic fungi | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-01 | — | — | US | disclosed |
| EP-2378880-A1 | USE OF 5-PYRIDIN-4YL(1,3)THIAZOLE FOR TREATING PHYTOPATHOGENIC FUNGI | BAYER CROPSCIENCE AG (DE) | 2011-10-26 | — | — | EP | disclosed |
| US-20100168185-A1 | Use of 5-pyridin-4-yl-1,3-thiazoles for controlling phytopathogenic fungi | BAYER CORPSCIENCE AG (DE) | 2010-07-01 | — | — | US | disclosed |
| WO-2010069494-A1 | USE OF 5-PYRIDIN-4YL(1,3)THIAZOLE FOR TREATING PHYTOPATHOGENIC FUNGI | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2010-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168185-A1 | Use of 5-pyridin-4-yl-1,3-thiazoles for controlling phytopathogenic fungi | PIR, PNPO, PDXK | PDPK1 571/4885LOXL2 870/4885HSP90AA1 3319/4885 |
| US-20210188836-A1 | 6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF RORyT | RORC, RORA, RORB | PDPK1 2419/4885LOXL2 3844/4885HSP90AA1 1500/4885 |
| US-10975068-B2 | 6-aminopyridin-3-yl thiazoles as modulators of RORγT | RORC, RORA, RORB | PDPK1 2428/4885LOXL2 4085/4885HSP90AA1 1142/4885 |
| US-20170313691-A1 | 6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF RORyT | RORC, RORA, RORB | PDPK1 2419/4885LOXL2 3844/4885HSP90AA1 1500/4885 |
| US-20210221804-A1 | 6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF RORyT | RORC, RORA, RORB | PDPK1 2419/4885LOXL2 3844/4885HSP90AA1 1500/4885 |
| US-20210198251-A1 | 6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF RORyT | RORC, RORA, RORB | PDPK1 2419/4885LOXL2 3844/4885HSP90AA1 1500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.