Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SLC15A1 | P46059 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | LAP3 | P28838 | 1/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2490609 | 0.98 | ALDH1A1 (0.51) | ALDH1A1SLC15A1KMT2AL3MBTL1MAPK1 | |
| SCHEMBL7694383 | 0.86 | ALDH1A1 (0.59) | ALDH1A1SLC15A1KMT2AL3MBTL1MAPK1 | |
| SCHEMBL3231535 | 0.85 | ALDH1A1 (0.55) | ALDH1A1SLC15A1KMT2AL3MBTL1MAPK1 | |
| SCHEMBL9852770 | 0.83 | ALDH1A1 (0.49) | ALDH1A1SLC15A1KMT2AL3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL27925213 | 0.83 | ALDH1A1 (0.53) | ALDH1A1SLC15A1KMT2AL3MBTL1MAPK1 | |
| SCHEMBL9081027 | 0.83 | ALDH1A1 (0.61) | ALDH1A1SLC15A1KMT2AL3MBTL1MAPK1 | |
| SCHEMBL9082362 | 0.83 | ALDH1A1 (0.61) | ALDH1A1SLC15A1KMT2AL3MBTL1MAPK1 | |
| SCHEMBL4788226 | 0.82 | ALDH1A1 (0.55) | ALDH1A1SLC15A1KMT2AL3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL9081023 | 0.81 | ALDH1A1 (0.59) | ALDH1A1SLC15A1KMT2AL3MBTL1MAPK1 | |
| SCHEMBL7424592 | 0.81 | ALDH1A1 (0.55) | ALDH1A1KMT2AL3MBTL1MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211914-B2 | Inhibitors of diacylglycerol acyltransferase | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-07-03 | — | — | US | disclosed |
| EP-2378878-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Via Pharmaceuticals, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010077861-A1 | INHIBITORS OF DIACYLGLYCEROL ACLYTRANSFERASE | VIA PHARMACEUTICALS, INC (US) | 2010-07-08 | — | — | WO | disclosed |
| US-20100152445-A1 | Inhibitors of Diacylglycerol Acyltransferase | MADRIGAL PHARMACEUTICALS, INC. | 2010-06-17 | — | — | US | disclosed |
| CN-1160343-C | Aminothiazole inhibitors of cyclin dependent protein kinasses of cells | ����˹�ж�-����˹˹������˾ | 2004-08-04 | — | — | CN | disclosed |
| CN-1433408-A | Aminothiazole inhibitors of cyslin dependent kinases | BRISTOL MYERS SQUIBB CO (US) | 2003-07-30 | — | — | CN | disclosed |
| CN-1278806-A | Aminothiazole inhibitors of cyclin dependent protein kinasses of cells | BRISTOL MYERS SQUIBB CO (US) | 2001-01-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152445-A1 | Inhibitors of Diacylglycerol Acyltransferase | DGAT2, DGAT1, ACAT2 | ALDH1A1 1249/4885SLC15A1 3352/4885KMT2A 845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.